UBA2

Gene Symbol	UBA2
Entrez Gene	10054
Alt Symbol	ARX, HRIHFB2115, SAE2
Species	Human
Gene Type	protein-coding
Description	ubiquitin-like modifier activating enzyme 2
Other Description	SUMO-1 activating enzyme subunit 2|SUMO-activating enzyme subunit 2|SUMO1 activating enzyme subunit 2|UBA2, ubiquitin-activating enzyme E1 homolog|anthracycline-associated resistance ARX|ubiquitin-like 1-activating enzyme E1B|ubiquitin-like modifier-activating enzyme 2
Swissprots	O95605 Q6IBP6 Q59H87 Q9UED2 Q9NTJ1 B3KWB9 Q9UBT2
Accessions	Q9UBT2 AB015337 BAA34795 AB208872 BAD92109 AF079566 AAD23914 AF090384 AAD12784 AF110957 AAD24434 AK023120 BAG51158 AK024114 BAG51265 AK124730 BAG54081 AK299514 BAH13056 AK315521 BAG37902 AL136905 CAB66839 BC003153 AAH03153 BG503066 BG678201 BM556031 BT009781 AAP88783 CR456756 CAG33037 DQ893423 ABM84349 EU176757 ABW03558 U35832 AAC99992 XM_005258404 XP_005258461 XM_006722962 XP_006723025 XM_011526304 XP_011524606 XR_935712 NM_005499 NP_005490
Function	The heterodimer acts as a E1 ligase for SUMO1, SUMO2, SUMO3, and probably SUMO4. It mediates ATP-dependent activation of SUMO proteins followed by formation of a thioester bond between a SUMO protein and a conserved active site cysteine residue on UBA2/SAE2. {ECO:0000269|PubMed:11451954, ECO:0000269|PubMed:11481243, ECO:0000269|PubMed:15660128, ECO:0000269|PubMed:17643372, ECO:0000269|PubMed:19443651, ECO:0000269|PubMed:20164921}.
Subcellular Location	Cytoplasm. Nucleus. Note=Shuttles between the cytoplasm and the nucleus, sumoylation is required either for nuclear translocation or nuclear retention.
Top Pathways	Ubiquitin mediated proteolysis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human SAE2 / UBA2 full length protein - ab140416 from Abcam Category Protein Source Baculovirus infected sf9 cells Species Human

Human SAE2 / UBA2 full length protein - ab132983 from Abcam Category Protein Source Wheat germ Species Human

S. cerevisiae SAE2 / UBA2 full length protein - ab80727 from Abcam Category Protein Source E. coli Species Yeast

SAE2 / UBA2 peptide - ab109093 from Abcam Category Peptide

SAE2 Recombinant Protein - H00010054-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

SAE2 Blocking Peptide - NBP1-77162PEP from Novus Biologicals Category Peptide Prices $129.00 Sizes 50 µg Species Human

SAE2 Peptide - P0182 from Novus Biologicals Category Peptide Species Human

SAE2-UBA2-Antibody-C-term-A600-Blocking-peptide - BP1065c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SAE2-UBA2-Antibody-C-term-E616-Blocking-peptide - BP1065b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBA2-Antibody-N-term-Blocking-Peptide - BP1065a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

UBA2 blocking peptide - GTX25646-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse

UBA2 Blocking Peptide - abx063642 from Abbexa Category Peptide Species Human

SAE2 / UBA2 Peptide - AC21-0431-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SAE2 / UBA2 - H00010054-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SAE2 / UBA2 - H00010054-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SAE2 / UBA2 control peptide - AP26207CP-N from Acris Antibodies Category Peptide Prices $135.00 Sizes 50 µg

SAE2 Peptide - 5751P from ProSci Category Peptide Species Human

SAE2 Peptide - 46-329P from ProSci Category Peptide

UBA2 fusion protein - Ag7586 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

UBA2 fusion protein - Ag7582 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human UBA2, GST-tagged - UBA2-253H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus Species Human

Recombinant Human UBA2, GST-tagged - UBA2-3515H from Creative Biomart Category Protein Source E.coli Species Human

UBA2(SAE2) protein-GST fusion - 009-001-U25 from Rockland Immunochemicals Inc Category Protein Prices $499.00 Sizes 50 µg Species Human

UBA2(SAE2) protein-GST fusion - 009-001-U25S from Rockland Immunochemicals Inc Category Protein Prices $265.00 Sizes 20 µg Species Human

UBA2 Blocking Peptide - CBP2448 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human

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