BAD

Gene Symbol	BAD
Entrez Gene	572
Alt Symbol	BBC2, BCL2L8
Species	Human
Gene Type	protein-coding
Description	BCL2-associated agonist of cell death
Other Description	BCL-X/BCL-2 binding protein|BCL2-antagonist of cell death protein|BCL2-binding component 6|BCL2-binding protein|bcl-2-binding component 6|bcl-2-like protein 8|bcl-XL/Bcl-2-associated death promoter|bcl2 antagonist of cell death|bcl2-L-8|bcl2-associated agonist of cell death
Swissprots	O14803 Q6FH21 Q92934
Accessions	EAW74233 EAW74234 EAW74235 EAW74236 Q92934 AB451254 BAG70068 AB451378 BAG70192 AF021792 AAB72092 AF031523 AAB88124 AK023420 AK291863 BAF84552 AK303051 BAG64171 AK309150 AW014069 BC001901 AAH01901 BC095431 AAH95431 BE255791 BG435829 BG748336 BT006678 AAP35324 CR541935 CAG46733 CR541959 CAG46757 DQ895784 ABM86710 EU176363 ABW03814 U66879 AAB36516 NM_004322 NP_004313 NM_032989 NP_116784
Function	Promotes cell death. Successfully competes for the binding to Bcl-X(L), Bcl-2 and Bcl-W, thereby affecting the level of heterodimerization of these proteins with BAX. Can reverse the death repressor activity of Bcl-X(L), but not that of Bcl-2 (By similarity). Appears to act as a link between growth factor receptor signaling and the apoptotic pathways. {ECO:0000250}.
Subcellular Location	Mitochondrion outer membrane. Cytoplasm {ECO:0000250|UniProtKB:Q61337}. Note=Colocalizes with HIF3A in the cytoplasm (By similarity). Upon phosphorylation, locates to the cytoplasm. {ECO:0000250|UniProtKB:Q61337}.
Tissue Specificity	Expressed in a wide variety of tissues.
Top Pathways	Apoptosis, Hepatitis C, cGMP-PKG signaling pathway, PI3K-Akt signaling pathway, Viral carcinogenesis

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Bad siRNA I - 6471 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol) Species Reactivities Human

SignalSilence ® Bad siRNA II - 6512 from Cell Signaling Technology Category siRNA Prices $256.00 Sizes 300 µl (3 nmol)

Bad CRISPR/Cas9 KO Plasmid (h) - sc-400419 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad HDR Plasmid (h) - sc-400419-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad Double Nickase Plasmid (h) - sc-400419-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad Double Nickase Plasmid (h2) - sc-400419-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad CRISPR Activation Plasmid (h) - sc-400419-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad CRISPR Activation Plasmid (h2) - sc-400419-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad Lentiviral Activation Particles (h) - sc-400419-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad Lentiviral Activation Particles (h2) - sc-400419-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Bad siRNA (h) - sc-29778 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bad shRNA Plasmid (h) - sc-29778-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bad shRNA (h) Lentiviral Particles - sc-29778-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Bad RNAi - H00000572-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU077271 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3834 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3834 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR03803 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr03803

BAD siRNA (Human) - CRH0390 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

Bad RNAi - H00000572-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

BAD - MBS8207054 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human BAD (NM_004322.3) - SHH244606 from Creative biogene Category siRNA Species Reactivities Human

BAD shRNA Plasmid (Human) - CHH0390 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

BAD miRNA 3'UTR clone - MiUTR3H-05733 from Creative biogene Species Reactivities Human

BAD miRNA 3'UTR clone - MiUTR3H-05734 from Creative biogene Species Reactivities Human

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