Gene Symbol | KDSR |
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Entrez Gene | 2531 |
Alt Symbol | DHSR, FVT1, SDR35C1 |
Species | Human |
Gene Type | protein-coding |
Description | 3-ketodihydrosphingosine reductase |
Other Description | 3-dehydrosphinganine reductase|FVT-1|KDS reductase|follicular lymphoma variant translocation 1|follicular variant translocation protein 1|short chain dehydrogenase/reductase family 35C member 1|short chain dehydrogenase/reductase family 35C, member 1 |
Swissprots | B2R5Y1 Q06136 B4DMX0 |
Accessions | EAW63140 EAW63141 Q06136 AF086045 AK025120 AK093874 AK126679 AK297670 BAG60032 AK312360 BAG35278 BC008797 AAH08797 BI458411 BT006782 AAP35428 X63657 CAA45197 XM_005266677 XP_005266734 XM_006722433 XP_006722496 NM_002035 NP_002026 |
Function | Catalyzes the reduction of 3-ketodihydrosphingosine (KDS) to dihydrosphingosine (DHS). |
Subcellular Location | Endoplasmic reticulum membrane {ECO:0000269|PubMed:15328338}; Multi-pass membrane protein {ECO:0000269|PubMed:15328338}. |
Tissue Specificity | Expressed in all tissues examined. Highest expression in placenta. High expression in lung, kidney, stomach and small intestine, low expression in heart, spleen and skeletal muscle. Weakly expressed in normal hematopoietic tissues. Higher expression in some T-cell malignancies and PHA-stimulated lymphocytes. |
Top Pathways | Sphingolipid metabolism |
FVT1 (D-15) - sc-84825 from Santa Cruz Biotechnology
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FVT1 (H-149) - sc-366781 from Santa Cruz Biotechnology
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FVT1 (S-18) - sc-84827 from Santa Cruz Biotechnology
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FVT1 (SS-7) - sc-100589 from Santa Cruz Biotechnology
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Anti-FVT1 antibody - ab58122 from Abcam
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Anti-FVT1 antibody - N-terminal - ab199857 from Abcam
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Anti-FVT1 / KDSR Antibody (aa1-333, clone 10C297, Azide-free) - LS-C183636 from LifeSpan Bioscience
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Anti-FVT1 / KDSR Antibody (aa73-122) - LS-C201489 from LifeSpan Bioscience
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Anti-FVT1 / KDSR Antibody (clone 2B2-3C11) - LS-C197254 from LifeSpan Bioscience
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FVT1 Antibody (2B2-3C11) - H00002531-M01 from Novus Biologicals
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FVT1 Antibody - NBP2-38534 from Novus Biologicals
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FVT1 Antibody - NBP2-14962 from Novus Biologicals
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FVT1 Antibody (3E8.) - H00002531-M09 from Novus Biologicals
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FVT1 Polyclonal Antibody - bs-13233R from Bioss
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FVT1 Polyclonal Antibody, ALEXA FLUOR® 350 Conjugated - bs-13233R-A350 from Bioss
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FVT1 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated - bs-13233R-A488 from Bioss
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FVT1 Polyclonal Antibody, ALEXA FLUOR® 555 Conjugated - bs-13233R-A555 from Bioss
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FVT1 Polyclonal Antibody, ALEXA FLUOR® 647 Conjugated - bs-13233R-A647 from Bioss
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FVT1 Polyclonal Antibody, Cy3 Conjugated - bs-13233R-Cy3 from Bioss
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FVT1 Polyclonal Antibody, Cy5 Conjugated - bs-13233R-Cy5 from Bioss
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FVT1 Polyclonal Antibody, Cy5.5 Conjugated - bs-13233R-Cy5.5 from Bioss
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FVT1 Polyclonal Antibody, Cy7 Conjugated - bs-13233R-Cy7 from Bioss
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FVT1 Polyclonal Antibody, FITC Conjugated - bs-13233R-FITC from Bioss
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FVT1 Polyclonal Antibody, Biotin Conjugated - bs-13233R-Biotin from Bioss
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FVT1 Polyclonal Antibody, HRP Conjugated - bs-13233R-HRP from Bioss
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