SMO

Gene Symbol SMO
Entrez Gene 6608
Alt Symbol FZD11, Gx, SMOH
Species Human
Gene Type protein-coding
Description smoothened, frizzled class receptor
Other Description frizzled family member 11|protein Gx|seven transmembrane helix receptor|smoothened homolog|smoothened, frizzled family receptor|smoothened, seven transmembrane spanning receptor
Swissprots A4D1K5 Q99835
Accessions AAD17202 BAC05807 EAL24102 EAW83715 Q99835 AF071494 AAC24863 AF089720 AF120103 AAF31757 AF130867 AAD28625 AU132302 BC004332 BC009989 AAH09989 DQ896647 ABM87646 U84401 AAB41788 XM_011516522 XP_011514824 NM_005631 NP_005622
Function G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. {ECO:0000269|PubMed:19592253}.
Subcellular Location Membrane {ECO:0000269|PubMed:22072986}; Multi-pass membrane protein {ECO:0000269|PubMed:22072986}. Cell projection, cilium {ECO:0000269|PubMed:22072986}.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma, Proteoglycans in cancer

Human SMO ORF clone(NM_005631.4) - CDCH401447 from Creative Biomart

Species Human
Accession NM_005631.4

human SMO ORF clone - CDCH083646 from Creative Biomart

Species Human
Accession NM_005631

human SMO ORF clone - CDCH083647 from Creative Biomart

Species Human
Accession NM_005631

Human SMO ORF clone(NM_005631.4) - CDCH401447 from Creative biogene

Species Human
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