SMO

Gene Symbol	SMO
Entrez Gene	6608
Alt Symbol	FZD11, Gx, SMOH
Species	Human
Gene Type	protein-coding
Description	smoothened, frizzled class receptor
Other Description	frizzled family member 11|protein Gx|seven transmembrane helix receptor|smoothened homolog|smoothened, frizzled family receptor|smoothened, seven transmembrane spanning receptor
Swissprots	A4D1K5 Q99835
Accessions	AAD17202 BAC05807 EAL24102 EAW83715 Q99835 AF071494 AAC24863 AF089720 AF120103 AAF31757 AF130867 AAD28625 AU132302 BC004332 BC009989 AAH09989 DQ896647 ABM87646 U84401 AAB41788 XM_011516522 XP_011514824 NM_005631 NP_005622
Function	G protein-coupled receptor that probably associates with the patched protein (PTCH) to transduce the hedgehog's proteins signal. Binding of sonic hedgehog (SHH) to its receptor patched is thought to prevent normal inhibition by patched of smoothened (SMO). Required for the accumulation of KIF7 and GLI3 in the cilia. {ECO:0000269|PubMed:19592253}.
Subcellular Location	Membrane {ECO:0000269|PubMed:22072986}; Multi-pass membrane protein {ECO:0000269|PubMed:22072986}. Cell projection, cilium {ECO:0000269|PubMed:22072986}.
Top Pathways	Hedgehog signaling pathway, Basal cell carcinoma, Proteoglycans in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human Smoothened peptide - ab39344 from Abcam Category Peptide

Human Smoothened protein fragment - ab112354 from Abcam Category Protein Source Wheat germ Species Human

Human Smoothened protein fragment - ab114221 from Abcam Category Protein Source Wheat germ Species Human

Human Smoothened protein fragment - ab114222 from Abcam Category Protein Source Wheat germ Species Human

Human Smoothened protein fragment - ab193861 from Abcam Category Protein Source Mammalian Species Human

SMO-Antibody-Center-Blocking-Peptide - BP16325c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Smoothened homolog (C Terminus) blocking peptide - GTX89213-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Dog, Bovine

Smoothened homolog (internal) blocking peptide - GTX89218-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Rat, Zebrafish

Smoothened Peptide - AC21-0824-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

Smoothened Peptide - AC21-1009-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

SMO - H00006608-G01 from Acris Antibodies Category Protein Prices $550.00 Sizes 10 µg Species Human

SMO - H00006608-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

SMO - H00006608-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

SMO - H00006608-Q02 from Acris Antibodies Category Protein Prices $370.00 Sizes 10 µg Species Human

SMO - H00006608-Q02-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMO - H00006608-Q02-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMO - H00006608-Q03-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

SMO - H00006608-Q03-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

SMO Control Peptide - AP05293CP-N from Acris Antibodies Category Peptide Prices $205.00 Sizes 50 µg

SMO Peptide - 46-388P from ProSci Category Peptide Species Human

SMO Peptide - 46-389P from ProSci Category Peptide Species Human

SMO fusion protein - Ag14322 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

SMO fusion protein - Ag16993 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

SMO fusion protein - ag13212 from Proteintech Group Category Protein Source E. coli-derived, PGEX-4T Species Human

Recombinant Human SMO - SMO-31421TH from Creative Biomart Category Protein Source Wheat germ

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