PRKCG

Gene Symbol PRKCG
Entrez Gene 5582
Alt Symbol PKC-gamma, PKCC, PKCG, SCA14
Species Human
Gene Type protein-coding
Description protein kinase C, gamma
Other Description protein kinase C gamma type
Swissprots B7Z8Q0 P05129
Accessions CAA44394 EAW72161 P05129 AB209671 BAD92908 AF345987 AAK13533 AK296412 BAH12345 AK296434 BAH12352 AK302958 BAH13856 AK303741 BAH14036 AK312302 BAG35228 BC047876 AAH47876 BI757265 M13977 AAA60102 Z15114 CAA78820 XM_011527107 XP_011525409 XM_011527108 XP_011525410 NM_002739 NP_002730
Function Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but ma
Subcellular Location Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P63318}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:P63318}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63319}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250|UniProtKB:P63318}.
Tissue Specificity Expressed in Purkinje cells of the cerebellar cortex. {ECO:0000269|PubMed:12644968}.
Top Pathways Thyroid hormone synthesis, Proteoglycans in cancer, Amphetamine addiction, Sphingolipid signaling pathway, Morphine addiction

HTScan® PKCγ Kinase Assay Kit - 7597 from Cell Signaling Technology

Category Assay Kit
Figure 1. PKCgamma kinase activity was measured in a radiometric assay using the following reaction conditions: 60 mM HEPES-NaOH, pH 7.5, 5 mM MgCl2, 1.32 mM CaCl2, 1 mM EDTA, 1.25 mM EGTA, 0.25 μg/50 μl Phosphatidylserine, 50 ng/50 μl 1.2 Dioleyl-glycerol, 1.2 mM DTT, ATP (variable), 2.5 μg/50 μl PEG 20.000, Substrate: Histone H1, 1 μg/50 μl recombinant PKCgamma: 100 ng/50 μl.

Human PRKCG / PKC-Gamma ELISA Kit (Sandwich ELISA) - LS-F11902 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 0.156
Range 0.156-10 ng/ml

Protein kinase C gamma type (PRKCG), Human, ELISA Kit - CSB-EL018705HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Protein kinase C gamma type, PRKCG, Human, ELISA Kit - E8823h from ARP American Research Products

Category ELISA Kit
Prices $660.00
Sizes 96 t
Range 0.156-10 ng/mL

Protein Kinase C Gamma, PKCg, Mouse, ELISA Kit - E-EL-M0976 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Protein Kinase C Gamma, PKCG, Rat, ELISA Kit - E-EL-R0811 from ARP American Research Products

Category ELISA Kit
Prices $585.00
Sizes 96 t

Human PKCg ELISA Kit - HP0111 from NeoScientific

Category ELISA Kit
Prices $495.00
Sizes 96 t

Anserine PKCg ELISA Kit - AP0111 from NeoScientific

Category ELISA Kit
Prices $380.00, $620.00
Sizes 100 µl, 200 µl

PKCG, ELISA Kit - MBS2515308 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 1.875ng/mL
Range 3.125-200ng/mL

PKCg, ELISA Kit - MBS2511359 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/mL
Range 0.625-40ng/mL

PKCgamma, ELISA Kit - MBS2505996 from MyBioSource

Category ELISA Kit
Prices $410.00, $490.00, $2,040.00, $3,590.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PKCgamma, ELISA Kit - MBS2508829 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PKCgamma, ELISA Kit - MBS2505010 from MyBioSource

Category ELISA Kit
Prices $490.00, $585.00, $2,475.00, $4,360.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.469ng/mL
Range 0.781-50ng/mL

PKCgamma, ELISA Kit - MBS2508125 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PKCgamma, ELISA Kit - MBS2515552 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.938ng/mL
Range 1.563-100ng/mL

PKCgamma, ELISA Kit - MBS2509768 from MyBioSource

Category ELISA Kit
Prices $450.00, $535.00, $2,255.00, $3,975.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity 0.375ng/mL
Range 0.625-40ng/mL

Protein Kinase C Gamma, ELISA Kit - MBS744967 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS037384 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS093705 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS723478 from MyBioSource

Category ELISA Kit
Prices $470.00, $675.00, $2,925.00, $5,490.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS056855 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS041503 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS036906 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS028975 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase C Gamma, ELISA Kit - MBS043319 from MyBioSource

Category ELISA Kit
Prices $435.00, $600.00, $2,650.00, $5,205.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
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