| Gene Symbol | PRKCG |
|---|---|
| Entrez Gene | 5582 |
| Alt Symbol | PKC-gamma, PKCC, PKCG, SCA14 |
| Species | Human |
| Gene Type | protein-coding |
| Description | protein kinase C, gamma |
| Other Description | protein kinase C gamma type |
| Swissprots | B7Z8Q0 P05129 |
| Accessions | CAA44394 EAW72161 P05129 AB209671 BAD92908 AF345987 AAK13533 AK296412 BAH12345 AK296434 BAH12352 AK302958 BAH13856 AK303741 BAH14036 AK312302 BAG35228 BC047876 AAH47876 BI757265 M13977 AAA60102 Z15114 CAA78820 XM_011527107 XP_011525409 XM_011527108 XP_011525410 NM_002739 NP_002730 |
| Function | Calcium-activated, phospholipid- and diacylglycerol (DAG)-dependent serine/threonine-protein kinase that plays diverse roles in neuronal cells and eye tissues, such as regulation of the neuronal receptors GRIA4/GLUR4 and GRIN1/NMDAR1, modulation of receptors and neuronal functions related to sensitivity to opiates, pain and alcohol, mediation of synaptic function and cell survival after ischemia, and inhibition of gap junction activity after oxidative stress. Binds and phosphorylates GRIA4/GLUR4 glutamate receptor and regulates its function by increasing plasma membrane-associated GRIA4 expression. In primary cerebellar neurons treated with the agonist 3,5-dihyidroxyphenylglycine, functions downstream of the metabotropic glutamate receptor GRM5/MGLUR5 and phosphorylates GRIN1/NMDAR1 receptor which plays a key role in synaptic plasticity, synaptogenesis, excitotoxicity, memory acquisition and learning. May be involved in the regulation of hippocampal long-term potentiation (LTP), but ma |
| Subcellular Location | Cytoplasm {ECO:0000250|UniProtKB:P63318}. Cytoplasm, perinuclear region {ECO:0000250}. Cell membrane {ECO:0000250|UniProtKB:P63318}; Peripheral membrane protein {ECO:0000250}. Cell junction, synapse, synaptosome {ECO:0000250|UniProtKB:P63318}. Cell projection, dendrite {ECO:0000250|UniProtKB:P63319}. Note=Translocates to synaptic membranes on stimulation. {ECO:0000250|UniProtKB:P63318}. |
| Tissue Specificity | Expressed in Purkinje cells of the cerebellar cortex. {ECO:0000269|PubMed:12644968}. |
| Top Pathways | Thyroid hormone synthesis, Proteoglycans in cancer, Amphetamine addiction, Sphingolipid signaling pathway, Morphine addiction |