Xbp1

Gene Symbol	Xbp1
Entrez Gene	22433
Alt Symbol	D11Ertd39e, TREB-5, TREB5, XBP-1
Species	Mouse
Gene Type	protein-coding
Description	X-box binding protein 1
Other Description	X-box-binding protein 1|tax-responsive element-binding protein 5 homolog
Swissprots	Q922G5 Q9ESS3 Q8VHM0 O35426
Accessions	BAB13793 EDL40531 EDL40532 EDL40533 EDL40534 O35426 AF027963 AAB81862 AF443192 AAL60202 AK007724 AK145241 AK178083 AK180092 AK183866 AK187998 AK191275 AK195676 AK201525 AK202632 AK204892 AK205453 AK206627 AK206863 AK207925 AK209182 AK211765 AK213043 AK216856 AK217319 AK217485 AK217614 AK217907 AK218355 AK218387 AK218413 AK219822 AK220033 BC003496 BC008153 AAH08153 BC016079 AAH16079 BC029197 AAH29197 BC035452 BF453945 BG800705 NM_001271730 NP_001258659 NM_013842 NP_038870
Function	Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11850408, PubMed:14559994). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation, and promotes as well membrane phospholipid biosynthesis necessary for ER expansion (PubMed:12612580, PubMed:17213183). Contributes to the VEGF- induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression. Promotes umbilical v
Subcellular Location	Isoform 2: Nucleus {ECO:0000250|UniProtKB:P17861, ECO:0000269|PubMed:16332684, ECO:0000269|PubMed:18556558, ECO:0000269|PubMed:20348926, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000269|PubMed:16332684}. Note=Localizes predominantly in the nucleus (PubMed:16332684). Colocalizes in the nucleus with SIRT1 (PubMed:20955178). Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (PubMed:20348926). {ECO:0000269|PubMed:16332684, ECO:0000269|PubMed:18556558, ECO:0000269|PubMed:20348926, ECO:0000269|PubMed:20955178}.
Tissue Specificity	Isoform 1 and isoform 2 are expressed at higher level in branch curves of vessel walls and in atherosclerotic plaques relative to healthy segments of the same aortas (at protein level) (PubMed:19416856). Expressed in skeletal muscles, plasma cells and pancreatic beta cells (PubMed:17612490). Isoform 1 and isoform 2 are expressed in gonadal adipose tissue. Isoform 1 is expressed in inguinal adipose tissue (PubMed:23623498). {ECO:0000269|PubMed:17612490, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23623498}.
Top Pathways	Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD)

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

X-Box Binding Protein 1 (XBP1), Mouse, ELISA Kit - SEC605Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

X-box-binding protein 1, Xbp1, Mouse, ELISA Kit - E9143m from ARP American Research Products Category ELISA Kit Prices $660.00 Sizes 96 t

X-Box Binding Protein 1 (XBP1), Mouse, CLIA Kit - SCC605Mu from ARP American Research Products Category CLIA Kit Prices $864.00 Sizes 96 t Sensitivity 0.051ng/mL Range 0.156-10ng/mL

ELISA Kit for X-Box Binding Protein 1 (XBP1) - SEC605Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.061ng/mL. Range 0.156-10ng/mL The standard curve concentrations used for the ELISA's were 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL, 0.156ng/mL

CLIA Kit for X-Box Binding Protein 1 (XBP1) - SCC605Mu from Cloud-clone Category CLIA Kit Sensitivity The minimum detectable dose of this kit is typically less than 6.06pg/mL. Range 13.717-10000pg/mL The standard curve concentrations used for the ELISA's were 10000pg/mL, 3333.33pg/mL, 1111.11pg/mL, 370.37pg/mL, 123.457pg/mL, 41.152pg/mL, 13.717pg/mL

Mouse XBP1 ELISA Kit - abx154867 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

X-Box Binding Protein 1 (XBP1), Mouse, ELISA Kit - DL-XBP1-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.156-10 ng/mL

Mouse XBP1 ELISA Kit - abx571162 from Abbexa Category ELISA Kit Sensitivity 0.061 ng/ml Range 0.156 ng/ml - 10 ng/ml

Mouse Xbp1 ELISA Kit - E072868 from Biobool Category ELISA Kit Sensitivity 0.1 ng/mL.

Mouse X-box-binding protein 1 (XBP1) ELISA Kit - AE11063MO from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

X-Box Binding Protein 1 (XBP1), ELISA Kit - MBS453711 from MyBioSource Category ELISA Kit Prices $425.00, $560.00, $2,480.00, $4,820.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 0.061ng/mL Range 0.156-10ng/mL

X-box-binding protein 1, ELISA Kit - MBS288616 from MyBioSource Category ELISA Kit Prices $430.00, $570.00, $2,515.00, $4,520.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

XBP1 Chemi-Luminescent ELISA Kit (Mouse) (OKCD04050) - OKCD04050 from Aviva Systems Biology Category ELISA Kit Sensitivity 0.156 ng/mL Range 0.156 - 10 ng/mL

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