| Gene Symbol | Xbp1 |
|---|---|
| Entrez Gene | 22433 |
| Alt Symbol | D11Ertd39e, TREB-5, TREB5, XBP-1 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | X-box binding protein 1 |
| Other Description | X-box-binding protein 1|tax-responsive element-binding protein 5 homolog |
| Swissprots | Q922G5 Q9ESS3 Q8VHM0 O35426 |
| Accessions | BAB13793 EDL40531 EDL40532 EDL40533 EDL40534 O35426 AF027963 AAB81862 AF443192 AAL60202 AK007724 AK145241 AK178083 AK180092 AK183866 AK187998 AK191275 AK195676 AK201525 AK202632 AK204892 AK205453 AK206627 AK206863 AK207925 AK209182 AK211765 AK213043 AK216856 AK217319 AK217485 AK217614 AK217907 AK218355 AK218387 AK218413 AK219822 AK220033 BC003496 BC008153 AAH08153 BC016079 AAH16079 BC029197 AAH29197 BC035452 BF453945 BG800705 NM_001271730 NP_001258659 NM_013842 NP_038870 |
| Function | Isoform 2: functions as a stress-inducible potent transcriptional activator during endoplasmic reticulum (ER) stress by inducing unfolded protein response (UPR) target genes via binding to the UPR element (UPRE). Up-regulates target genes encoding ER chaperones and ER-associated degradation (ERAD) components to enhance the capacity of productive folding and degradation mechanism, respectively, in order to maintain the homeostasis of the ER under ER stress (PubMed:11850408, PubMed:14559994). Plays a role in the production of immunoglobulins and interleukin-6 in the presence of stimuli required for plasma cell differentiation, and promotes as well membrane phospholipid biosynthesis necessary for ER expansion (PubMed:12612580, PubMed:17213183). Contributes to the VEGF- induced endothelial cell (EC) growth and proliferation in a Akt/GSK-dependent and/or -independent signaling pathway, respectively, leading to beta-catenin nuclear translocation and E2F2 gene expression. Promotes umbilical v |
| Subcellular Location | Isoform 2: Nucleus {ECO:0000250|UniProtKB:P17861, ECO:0000269|PubMed:16332684, ECO:0000269|PubMed:18556558, ECO:0000269|PubMed:20348926, ECO:0000269|PubMed:20955178}. Cytoplasm {ECO:0000269|PubMed:16332684}. Note=Localizes predominantly in the nucleus (PubMed:16332684). Colocalizes in the nucleus with SIRT1 (PubMed:20955178). Translocates into the nucleus in a PIK3R-, ER stress-induced- and/or insulin-dependent manner (PubMed:20348926). {ECO:0000269|PubMed:16332684, ECO:0000269|PubMed:18556558, ECO:0000269|PubMed:20348926, ECO:0000269|PubMed:20955178}. |
| Tissue Specificity | Isoform 1 and isoform 2 are expressed at higher level in branch curves of vessel walls and in atherosclerotic plaques relative to healthy segments of the same aortas (at protein level) (PubMed:19416856). Expressed in skeletal muscles, plasma cells and pancreatic beta cells (PubMed:17612490). Isoform 1 and isoform 2 are expressed in gonadal adipose tissue. Isoform 1 is expressed in inguinal adipose tissue (PubMed:23623498). {ECO:0000269|PubMed:17612490, ECO:0000269|PubMed:19416856, ECO:0000269|PubMed:23623498}. |
| Top Pathways | Protein processing in endoplasmic reticulum, HTLV-I infection, Non-alcoholic fatty liver disease (NAFLD) |