| Gene Symbol |
CRX
|
| Entrez Gene |
1406
|
| Alt Symbol |
CORD2, CRD, LCA7, OTX3
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
cone-rod homeobox
|
| Other Description |
cone-rod homeobox protein|orthodenticle homeobox 3
|
| Swissprots |
O43186 Q0QD45
|
| Accessions |
AAB88418 EAW57515 O43186 AF335247 AF335249 AF335593 AF335594 AF335595 AF442496 AL711350 BC009045 BC016664 AAH16664 BC053672 AAH53672 BT007364 AAP36028 BU736672 DQ340179 ABC69290 DQ426867 DQ426868 ABD90533 DQ893564 ABM84490 DQ894239 ABM85165 EF432655 ABO31091 NM_000554 NP_000545
|
| Function |
Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. {ECO:0000269|PubMed:10625658}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}.
|
| Tissue Specificity |
Retina.
|
![Western Blot: CORD2 Overexpression Lysate (Adult Normal) [NBL1-09494] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for CORD2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/1496_CORD2%2520Overexpression%2520Lysate%2520(Adult%2520Normal)-Western%2520Blot-NBL1-09494-img0002.jpg)