Gene Symbol | CRX |
---|---|
Entrez Gene | 1406 |
Alt Symbol | CORD2, CRD, LCA7, OTX3 |
Species | Human |
Gene Type | protein-coding |
Description | cone-rod homeobox |
Other Description | cone-rod homeobox protein|orthodenticle homeobox 3 |
Swissprots | O43186 Q0QD45 |
Accessions | AAB88418 EAW57515 O43186 AF335247 AF335249 AF335593 AF335594 AF335595 AF442496 AL711350 BC009045 BC016664 AAH16664 BC053672 AAH53672 BT007364 AAP36028 BU736672 DQ340179 ABC69290 DQ426867 DQ426868 ABD90533 DQ893564 ABM84490 DQ894239 ABM85165 EF432655 ABO31091 NM_000554 NP_000545 |
Function | Transcription factor that binds and transactivates the sequence 5'-TAATC[CA]-3' which is found upstream of several photoreceptor-specific genes, including the opsin genes. Acts synergistically with other transcription factors, such as NRL, RORB and RAX, to regulate photoreceptor cell-specific gene transcription. Essential for the maintenance of mammalian photoreceptors. {ECO:0000269|PubMed:10625658}. |
Subcellular Location | Nucleus {ECO:0000255|PROSITE- ProRule:PRU00108}. |
Tissue Specificity | Retina. |