EXOSC10
| Gene Symbol | EXOSC10 |
|---|---|
| Entrez Gene | 5394 |
| Alt Symbol | PM-Scl, PM/Scl-100, PMSCL, PMSCL2, RRP6, Rrp6p, p2, p3, p4 |
| Species | Human |
| Gene Type | protein-coding |
| Description | exosome component 10 |
| Other Description | P100 polymyositis-scleroderma overlap syndrome-associated autoantigen|autoantigen PM-SCL|polymyositis/scleroderma autoantigen 100 kDa|polymyositis/scleroderma autoantigen 2 |
| Swissprots | Q01780 B1AKQ1 Q15158 B1AKQ0 |
| Accessions | AAF73199 CAC15569 CAV30720 CAV30721 CCQ43005 EAW71677 EAW71678 EAW71679 Q01780 AB209236 BAD92473 AK093955 AK123365 AK294058 BAG57405 AK296559 BAG59180 AK308778 BC008460 BC009908 AAH09908 BC028687 BC039901 AAH39901 BC073788 AAH73788 CA307576 DA505395 EU832630 ACE87721 EU832705 ACE87037 L01457 AAB59352 X66113 CAA46904 XM_005263475 XP_005263532 XM_005263476 XP_005263533 XM_011541595 XP_011539897 NM_001001998 NP_001001998 NM_002685 NP_002676 |
| Function | Putative catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cytoplasm. The RNA exosome may be involved in Ig class switch recombination (CSR) and/or Ig variable region somatic hypermutation (SHM) by targeting AICDA deamination activity to transcribed dsDNA substrates. In the cytoplasm, the RNA exosome complex is involved in general mRNA turnover and specifically degrades inherently unstable mRNAs containing AU-rich elements (AREs) within their 3' untranslated regions, and in RNA surveillance pat |
| Subcellular Location | Cytoplasm. Nucleus, nucleolus. Nucleus. Note=Strongly enriched in the nucleolus and a small amount has been found in cytoplasm supporting the existence of a nucleolar RNA exosome complex form. |
| Top Pathways | RNA degradation |
EXOSC10 CRISPR/Cas9 KO Plasmid (h) - sc-404272 from Santa Cruz Biotechnology
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EXOSC10 HDR Plasmid (h) - sc-404272-HDR from Santa Cruz Biotechnology
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EXOSC10 Double Nickase Plasmid (h) - sc-404272-NIC from Santa Cruz Biotechnology
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EXOSC10 Double Nickase Plasmid (h2) - sc-404272-NIC-2 from Santa Cruz Biotechnology
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EXOSC10 CRISPR Activation Plasmid (h) - sc-404272-ACT from Santa Cruz Biotechnology
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EXOSC10 CRISPR Activation Plasmid (h2) - sc-404272-ACT-2 from Santa Cruz Biotechnology
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EXOSC10 Lentiviral Activation Particles (h) - sc-404272-LAC from Santa Cruz Biotechnology
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EXOSC10 Lentiviral Activation Particles (h2) - sc-404272-LAC-2 from Santa Cruz Biotechnology
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EXOSC10 siRNA (h) - sc-88207 from Santa Cruz Biotechnology
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EXOSC10 shRNA Plasmid (h) - sc-88207-SH from Santa Cruz Biotechnology
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EXOSC10 shRNA (h) Lentiviral Particles - sc-88207-V from Santa Cruz Biotechnology
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Exosome component 10 RNAi - H00005394-R05 from Novus Biologicals
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MISSION® esiRNA - EHU082601 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN8046 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND8046 from Sigma-Aldrich
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EXOSC10 siRNA (Human) - CRH3613 from Cohesion Biosciences
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Exosome component 10 RNAi - H00005394-R06 from Novus Biologicals
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EXOSC10 - MBS8228087 from MyBioSource
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shRNA set against Human EXOSC10(NM_002685.2) - SHH041969 from Creative biogene
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shRNA set against Human EXOSC10(NM_001001998.1) - SHH041987 from Creative biogene
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Human EXOSC10 siRNA - orb264115 from Biorbyt
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EXOSC10 shRNA Plasmid (Human) - CHH3613 from Cohesion Biosciences
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EXOSC10 miRNA 3'UTR clone - MiUTR1H-03345 from Creative biogene
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EXOSC10 miRNA 3'UTR clone - MiUTR1H-03346 from Creative biogene
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