DGAT1

Gene Symbol DGAT1
Entrez Gene 8694
Alt Symbol ARAT, ARGP1, DGAT, DIAR7
Species Human
Gene Type protein-coding
Description diacylglycerol O-acyltransferase 1
Other Description ACAT related gene product 1|acyl coenzyme A:cholesterol acyltransferase related gene 1|acyl-CoA retinol O-fatty-acyltransferase|acyl-CoA:diacylglycerol acyltransferase|diglyceride acyltransferase
Swissprots B2RWQ2 Q96BB8 O75907 D3DWL6
Accessions EAW82127 EAW82128 EAW82129 EAW82130 O75907 AB057815 BAC66170 AF059202 AAC63997 BC006263 AAH06263 BC015762 AAH15762 BC023565 AAH23565 BC106084 AAI06085 BC150649 AAI50650 BI907285 CK300256 DQ892286 ABM83212 DQ895486 ABM86412 HY016503 XM_011517356 XP_011515658 NM_012079 NP_036211
Function Catalyzes the terminal and only committed step in triacylglycerol synthesis by using diacylglycerol and fatty acyl CoA as substrates. In contrast to DGAT2 it is not essential for survival. May be involved in VLDL (very low density lipoprotein) assembly. In liver, plays a role in esterifying exogenous fatty acids to glycerol. Functions as the major acyl-CoA retinol acyltransferase (ARAT) in the skin, where it acts to maintain retinoid homeostasis and prevent retinoid toxicity leading to skin and hair disorders. {ECO:0000269|PubMed:16214399, ECO:0000269|PubMed:9756920}.
Subcellular Location Endoplasmic reticulum membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}.
Top Pathways Fat digestion and absorption, Glycerolipid metabolism, Retinol metabolism

Human DGAT1 ORF clone(NM_012079.4) - CDCH385406 from Creative Biomart

Species Human
Accession NM_012079.4

Human DGAT1 ORF Clone(NM_012079.4) - CDCL160959 from Creative Biomart

Species Human
Accession NM_012079.4

Human DGAT1 ORF clone (NM_012079.4) - CDCR055104 from Creative biogene

Species Human
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