| Gene Symbol |
Hes1
|
| Entrez Gene |
15205
|
| Alt Symbol |
Hry, bHLHb39
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
hairy and enhancer of split 1 (Drosophila)
|
| Other Description |
transcription factor HES-1
|
| Swissprots |
P35428
|
| Accessions |
BAA03931 EDK97718 P35428 AK132536 BAE21226 AK133538 BAE21713 BC018375 AAH18375 BC051428 AAH51428 XM_006521797 XP_006521860 NM_008235 NP_032261
|
| Function |
Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds.
|
| Top Pathways |
Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway
|