| Gene Symbol | Hes1 |
|---|---|
| Entrez Gene | 15205 |
| Alt Symbol | Hry, bHLHb39 |
| Species | Mouse |
| Gene Type | protein-coding |
| Description | hairy and enhancer of split 1 (Drosophila) |
| Other Description | transcription factor HES-1 |
| Swissprots | P35428 |
| Accessions | BAA03931 EDK97718 P35428 AK132536 BAE21226 AK133538 BAE21713 BC018375 AAH18375 BC051428 AAH51428 XM_006521797 XP_006521860 NM_008235 NP_032261 |
| Function | Transcriptional repressor of genes that require a bHLH protein for their transcription. May act as a negative regulator of myogenesis by inhibiting the functions of MYOD1 and ASH1 (By similarity). Binds DNA on N-box motifs: 5'-CACNAG-3' with high affinity and on E-box motifs: 5'-CANNTG-3' with low affinity. May play a role in a functional FA core complex response to DNA cross- link damage, being required for the stability and nuclear localization of FA core complex proteins, as well as for FANCD2 monoubiquitination in response to DNA damage (By similarity). {ECO:0000250}. |
| Subcellular Location | Nucleus. |
| Tissue Specificity | Expressed at high levels in undifferentiated neural precursor cells, but the level of expression decreases as neural differentiation proceeds. |
| Top Pathways | Notch signaling pathway, Maturity onset diabetes of the young, Fanconi anemia pathway |