| Gene Symbol |
POLR3F
|
| Entrez Gene |
10621
|
| Alt Symbol |
RPC39, RPC6
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
polymerase (RNA) III (DNA directed) polypeptide F, 39 kDa
|
| Other Description |
DNA-directed RNA polymerase III subunit RPC6|RNA polymerase III C39 subunit|RNA polymerase III subunit C6
|
| Swissprots |
O15319 Q9H1D9 A8K4C7
|
| Accessions |
EAX10239 EAX10240 EAX10241 Q9H1D9 AK096684 AK223298 BAD97018 AK290892 BAF83581 AK314838 BC012588 AAH12588 BC016761 AAH16761 DA729767 DQ892695 ABM83621 DQ896169 ABM87168 N98418 U93869 AAB63677 XM_011529141 XP_011527443 XR_937031 NM_001282526 NP_001269455 NM_006466 NP_006457 NR_104209
|
| Function |
DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific peripheric component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct RNA Pol III binding to the TFIIIB-DNA complex. Plays a key role in sensing and limiting infection by intracellular bacteria and DNA viruses. Acts as nuclear and cytosolic DNA sensor involved in innate immune response. Can sense non-self dsDNA that serves as template for transcription into dsRNA. The non-self RNA polymerase III transcripts, such as Epstein-Barr virus-encoded RNAs (EBERs) induce type I interferon and NF- Kappa-B through the RIG-I pathway. {ECO:0000269|PubMed:19609254, ECO:0000269|PubMed:19631370}.
|
| Subcellular Location |
Nucleus {ECO:0000250}.
|
| Top Pathways |
Cytosolic DNA-sensing pathway, Epstein-Barr virus infection, Purine metabolism, RNA polymerase, Pyrimidine metabolism
|