| Gene Symbol |
ZFHX3
|
| Entrez Gene |
463
|
| Alt Symbol |
ATBF1, ATBT, ZNF927
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
zinc finger homeobox 3
|
| Other Description |
AT motif-binding factor 1|AT-binding transcription factor 1|ZFH-3|alpha-fetoprotein enhancer binding protein|alpha-fetoprotein enhancer-binding protein|zinc finger homeobox protein 3|zinc finger homeodomain protein 3
|
| Swissprots |
O15101 Q13719 D3DWS8 Q15911
|
| Accessions |
AAC31674 AAC79153 AAR26475 EAW59168 EAW59169 EAW59170 Q15911 BC029653 AAH29653 BC043190 D10250 BAA01095 L32832 AAC14462 L32833 AAC37582 XM_005255957 XP_005256014 NM_001164766 NP_001158238 NM_006885 NP_008816
|
| Function |
Transcriptional repressor. It inhibits the enhancer element of the AFP gene by binding to its AT-rich core sequence. Regulator of myoblasts differentiation through the binding to the AT-rich sequence of MYF6 promoter and promoter repression. Down- regulates the MUC5AC promoter in gastric cancer. {ECO:0000269|PubMed:11312261, ECO:0000269|PubMed:17330845}.
|
| Subcellular Location |
Nucleus.
|
| Tissue Specificity |
Not found in normal gastric mucosa but found in gastric carcinoma cells (at protein level). {ECO:0000269|PubMed:17330845}.
|
| Top Pathways |
Signaling pathways regulating pluripotency of stem cells
|