| Gene Symbol | HSPB1 |
|---|---|
| Entrez Gene | 3315 |
| Alt Symbol | CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27 |
| Species | Human |
| Gene Type | protein-coding |
| Description | heat shock 27kDa protein 1 |
| Other Description | 28 kDa heat shock protein|HSP 27|epididymis secretory protein Li 102|estrogen-regulated 24 kDa protein|heat shock 27 kDa protein|heat shock 27kD protein 1|heat shock protein beta-1|stress-responsive protein 27 |
| Swissprots | Q6FI47 Q96EI7 Q9UC35 Q96C20 B2R4N8 Q9UC36 Q9UC31 P04792 Q9UC34 |
| Accessions | AAA62175 ABC88475 CDM22284 EAW71803 P04792 AB020027 BAB17232 AF086135 AK296890 BAG59449 AK311446 AK311894 BAG34835 AL050380 BC000510 AAH00510 BC012292 AAH12292 BC012768 AAH12768 BC014920 AAH14920 BC073768 AAH73768 BP231480 BT019888 AAV38691 CR407614 CAG28542 CR536489 CAG38728 DQ891304 ABM82230 DQ893349 ABM84275 DQ894489 ABM85415 DQ896669 ABM87668 FJ224323 ACI46015 S74571 AAB20722 U90906 AAB51056 X16477 CAA34498 X54079 CAA38016 NM_001540 NP_001531 |
| Function | Involved in stress resistance and actin organization. |
| Subcellular Location | Cytoplasm. Nucleus. Cytoplasm, cytoskeleton, spindle. Note=Cytoplasmic in interphase cells. Colocalizes with mitotic spindles in mitotic cells. Translocates to the nucleus during heat shock and resides in sub-nuclear structures known as SC35 speckles or nuclear splicing speckles. |
| Tissue Specificity | Detected in all tissues tested: skeletal muscle, heart, aorta, large intestine, small intestine, stomach, esophagus, bladder, adrenal gland, thyroid, pancreas, testis, adipose tissue, kidney, liver, spleen, cerebral cortex, blood serum and cerebrospinal fluid. Highest levels are found in the heart and in tissues composed of striated and smooth muscle. {ECO:0000269|PubMed:1560006}. |
| Top Pathways | VEGF signaling pathway, MAPK signaling pathway, Amoebiasis, Epstein-Barr virus infection |