| Gene Symbol |
Nr1i2
|
| Entrez Gene |
18171
|
| Alt Symbol |
PXR, PXR.1, PXR.2, PXR1, SXR, mPXR
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
nuclear receptor subfamily 1, group I, member 2
|
| Other Description |
Pregnane X receptor|nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PXR
|
| Swissprots |
O54915
|
| Accessions |
EDK97971 O54915 AF031814 AAC39964 AI595758 AI746915 AK011108 BAB27404 AK018630 BAB31316 BC120796 AAI20797 BC137780 AAI37781 CK383398 XM_006521846 XP_006521909 XM_006521847 XP_006521910 XM_006521848 XP_006521911 XM_011245839 XP_011244141 XM_011245840 XP_011244142 XR_384533 NM_001098404 NP_001091874 NM_010936 NP_035066
|
| Function |
Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand- binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN). {ECO:0000250, ECO:0000269|PubMed:12569201, ECO:0000269|PubMed:19297428}.
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.
|
