Nr1i2

Gene Symbol	Nr1i2
Entrez Gene	18171
Alt Symbol	PXR, PXR.1, PXR.2, PXR1, SXR, mPXR
Species	Mouse
Gene Type	protein-coding
Description	nuclear receptor subfamily 1, group I, member 2
Other Description	Pregnane X receptor|nuclear receptor subfamily 1 group I member 2|orphan nuclear receptor PXR
Swissprots	O54915
Accessions	EDK97971 O54915 AF031814 AAC39964 AI595758 AI746915 AK011108 BAB27404 AK018630 BAB31316 BC120796 AAI20797 BC137780 AAI37781 CK383398 XM_006521846 XP_006521909 XM_006521847 XP_006521910 XM_006521848 XP_006521911 XM_011245839 XP_011244141 XM_011245840 XP_011244142 XR_384533 NM_001098404 NP_001091874 NM_010936 NP_035066
Function	Nuclear receptor that binds and is activated by a variety of endogenous and xenobiotic compounds. Transcription factor that activates the transcription of multiple genes involved in the metabolism and secretion of potentially harmful xenobiotics, endogenous compounds and drugs. Response to specific ligands is species-specific, due to differences in the ligand- binding domain. Binds to a response element in the promoters of the CYP3A4 and ABCB1/MDR1 genes (By similarity). Activated by naturally occurring steroids such as pregnenolone and progesterone, the cholesterol metabolite 5-beta-cholestane-3- alpha,7-alpha,12-alpha-triol, synthetic glucocorticoids and antiglucocorticoids and 16-alpha-carbonitrile (PCN). {ECO:0000250, ECO:0000269|PubMed:12569201, ECO:0000269|PubMed:19297428}.
Subcellular Location	Nucleus {ECO:0000255|PROSITE- ProRule:PRU00407}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse Pregnane X Receptor Protein - abx068663 from Abbexa Category Protein Source E.coli Species Mouse

Pregnane X Receptor (PXR), Mouse - 20-8870 from ARP American Research Products Category Protein Prices $549.00 Sizes 50 µg Source E.coli Species Mouse

Recombinant Pregnane X Receptor (PXR) - RPD950Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse Nuclear receptor subfamily 1 group I member 2(Nr1i2) - CSB-YP016048MO CSB-EP016048MO CSB-BP016048MO CSB-MP016048MO from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Mouse

Pregnane X Receptor (PXR) - RPU143410 from Biomatik Category Protein Prices $264.00, $528.00, $792.00 Sizes 10 µg, 50 µg, 100 µg Source E.coli Species Mouse

Pregnane X Receptor (PXR), Recombinant Protein - MBS2012361 from MyBioSource Category Protein Prices $200.00, $430.00, $665.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Recombinant Mouse NR1I2 Protein - NR1I2-10859M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

Recombinant Pregnane X Receptor (PXR) - RPU43410 from Biomatik Category Protein Prices $211.00, $413.00, $660.00, $787.20 Sizes 10 µg, 50 µg, 100 µg, 200 µg Source E.coli Species Mouse

NR1I2 Recombinant Protein (OPCD06546) - OPCD06546 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Nuclear receptor subfamily 1 group I member 2 (Nr1i2), Recombinant Protein - MBS1232397 from MyBioSource Category Protein Prices $1,210.00, $1,210.00, $1,425.00, $1,425.00, $1,950.00, $1,950.00, $2,415.00, $2,415.00 Sizes 500 µg (E-Coli), 50 µg (Baculovirus), 500 µg (Yeast), 50 µg (Mammalian-Cell), 1 mg (E-Coli), 100 µg (Baculovirus), 1 mg (Yeast), 100 µg (Mammalian-Cell) Source E Coli or Yeast or Baculovirus or Mammalian Cell Species Mouse

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