PPP2R5B

Gene Symbol PPP2R5B
Entrez Gene 5526
Alt Symbol B56B, PR61B
Species Human
Gene Type protein-coding
Description protein phosphatase 2, regulatory subunit B', beta
Other Description PP2A B subunit isoform B'-beta|PP2A B subunit isoform B56-beta|PP2A B subunit isoform PR61-beta|PP2A B subunit isoform R5-beta|protein phosphatase 2, regulatory subunit B', beta isoform|serine/threonine protein phosphatase 2A, 56 kDa regulatory subunit, beta isoform|serine/threonine-protein phosphatase 2A 56 kDa regulatory subunit beta isoform
Swissprots Q13853 Q15173
Accessions EAW74324 EAW74325 Q15173 AK092730 BC045619 AAH45619 BE883575 BM665417 EU446998 ABZ92527 L42374 AAC37602 XM_006718607 XP_006718670 XM_011545132 XP_011543434 XM_011545133 XP_011543435 XM_011545134 XP_011543436 NM_006244 NP_006235
Function The B regulatory subunit might modulate substrate selectivity and catalytic activity, and also might direct the localization of the catalytic enzyme to a particular subcellular compartment. The phosphorylated form mediates the interaction between AKT1 and PP2A phosphatase leading to dephosphorylation of AKT1 on the 'Thr-308' and 'Ser-373' residues. {ECO:0000269|PubMed:21329884}.
Subcellular Location Cytoplasm {ECO:0000269|PubMed:8703017}.
Tissue Specificity Highest expression in brain.
Top Pathways Oocyte meiosis, mRNA surveillance pathway, Dopaminergic synapse, PI3K-Akt signaling pathway, Adrenergic signaling in cardiomyocytes

PP2A-B56-β siRNA (h) - sc-39183 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PP2A-B56-β shRNA Plasmid (h) - sc-39183-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

PP2A-B56-β shRNA (h) Lentiviral Particles - sc-39183-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU089081 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

MISSION® Human Phosphatase - SIHP0639 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0638 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

MISSION® Human Phosphatase - SIHP0637 from Sigma-Aldrich

Category siRNA
Prices $25.00
Sizes 250 pmol

CompoZr® Knockout ZFN Kit - CKOZFN17300 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND17300 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR05455 from Sigma-Aldrich

Category miRNA
Prices $350.00
Sizes hutr05455

PPP2R5B siRNA (Human) - CRH3705 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PPP2R5B RNAi - H00005526-R01 from Novus Biologicals

Category siRNA
Prices $399.00
Sizes 20 nmol
Species Reactivities Human

shRNA set against Human PPP2R5B (NM_006244.3) - SHH381484 from Creative biogene

Category siRNA
Species Reactivities Human

Human PPP2R5B siRNA - orb264207 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

PPP2R5B shRNA Plasmid (Human) - CHH3705 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

PPP2R5B miRNA 3'UTR clone - MiUTR3H-04281 from Creative biogene

Species Reactivities Human
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