ATP7A

Gene Symbol ATP7A
Entrez Gene 538
Alt Symbol DSMAX, MK, MNK, SMAX3
Species Human
Gene Type protein-coding
Description ATPase, Cu++ transporting, alpha polypeptide
Other Description Cu++-transporting P-type ATPase|Menkes disease-associated protein|copper pump 1|copper-transporting ATPase 1
Swissprots O00227 Q9BYY8 B1AT72 O00745 Q04656
Accessions AAA96010 AAG47452 CAB08160 CAB08162 CAB94714 CBL93959 EAW98605 EAW98606 Q04656 AB117973 BAC82353 AB208828 BAD92065 AK096667 AK299449 BAG61422 BC156437 AAI56438 BP364137 BU753163 BX503903 CD299174 DB164588 L06133 AAA35580 L06476 AAA16974 NM_000052 NP_000043 NM_001282224 NP_001269153 NR_104109
Function May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Subcellular Location Isoform 5: Endoplasmic reticulum.
Tissue Specificity Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines.
Top Pathways Mineral absorption

ATP7A (D-9) - sc-376467 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
ATP7A (D-9): sc-376467. Immunoperoxidase staining of formalin fixed, paraffin-embedded human pancreas tissue showing cytoplasmic staining of Islets of Langerhans and glandular cells.

ATP7A (C-20) - sc-30858 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

ATP7A (H-180) - sc-32900 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal

ATP7A (N-15) - sc-30856 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ATP7A (N-15): sc-30856. Immunoperoxidase staining of formalin fixed, paraffin-embedded human hippo-campus tissue showing cytoplasmic and membrane staining of neuronal cells and cytoplasmic staining of glial cells.

Anti-ATP7A antibody - ab13995 from Abcam

Prices $376.00
Sizes 50 µg
Host Chicken
Clonality Polyclonal

Anti-ATP7A antibody - ab125137 from Abcam

Prices $378.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab125137 stained MEF1 cells. The cells were 4% formaldehyde fixed (1 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab125137, 5µg/ml) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ATP7A antibody [S60-4] - ab131400 from Abcam

Prices $378.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4
Overlay histogram showing HT1080 cells stained with ab131400 (red line). The cells were fixed with 4% paraformaldehyde (10 min) and then permeabilized with 0.1% PBS-Tween for 20 min. The cells were then incubated in 1x PBS / 10% normal goat serum / 0.3M glycine to block non-specific protein-protein interactions followed by the antibody (ab131400, 0.1μg/1x106 cells) for 30 min at 22°C. The secondary antibody used was Alexa Fluor® 488 goat anti-mouse IgG (H+L) (ab150113) at 1/2000 dilution for 30 min at 22°C. Isotype control antibody (black line) was mouse IgG2b [PLPV219] (ab91366, 1μg/1x106 cells) used under the same conditions. Unlabelled sample (blue line) was also used as a control. Acquisition of >5,000 events were collected using a 20mW Argon ion laser (488nm) and 525/30 bandpass filter. This antibody gave a positive signal in HT1080 cells fixed with 80% methanol (5 min)/permeabilized with 0.1% PBS-Tween for 20 min used under the same conditions.

Anti-MNK / ATP7A Antibody (aa160-176) - LS-C3139 from LifeSpan Bioscience

Prices $265.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MNK / ATP7A Antibody (aa1212-1225) - LS-C87264 from LifeSpan Bioscience

Prices $335.00
Sizes 100 µg
Host Goat
Clonality Polyclonal

Anti-MNK / ATP7A Antibody (His640) - LS-C177735 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MNK / ATP7A Antibody (C-Terminus) - LS-C182994 from LifeSpan Bioscience

Prices $650.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MNK / ATP7A Antibody (aa591-640) - LS-C199773 from LifeSpan Bioscience

Host Rabbit
Clonality Polyclonal

Anti-MNK / ATP7A Antibody (C-Terminus) - LS-C209614 from LifeSpan Bioscience

Prices $515.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-MNK / ATP7A Antibody (C-Terminus) - LS-C31542 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
A: Marker, B: HepG2 Cell Lysate

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, Atto 390) - LS-C228579 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, Atto 488) - LS-C228580 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, Atto 565) - LS-C228581 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, Atto 594) - LS-C228582 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, Atto 655) - LS-C228584 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, Atto 633) - LS-C228583 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, FITC) - LS-C228585 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa1403-1452) - LS-C109828 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ATP7A antibody LS-C109828 Western blot of HT1080 cell lysate.

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, PE, Atto 594) - LS-C228587 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, PerCP) - LS-C228588 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4

Anti-MNK / ATP7A Antibody (aa42-61, clone S60-4, RPE) - LS-C228589 from LifeSpan Bioscience

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone S60-4
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