ATP7A

Gene Symbol ATP7A
Entrez Gene 538
Alt Symbol DSMAX, MK, MNK, SMAX3
Species Human
Gene Type protein-coding
Description ATPase, Cu++ transporting, alpha polypeptide
Other Description Cu++-transporting P-type ATPase|Menkes disease-associated protein|copper pump 1|copper-transporting ATPase 1
Swissprots O00227 Q9BYY8 B1AT72 O00745 Q04656
Accessions AAA96010 AAG47452 CAB08160 CAB08162 CAB94714 CBL93959 EAW98605 EAW98606 Q04656 AB117973 BAC82353 AB208828 BAD92065 AK096667 AK299449 BAG61422 BC156437 AAI56438 BP364137 BU753163 BX503903 CD299174 DB164588 L06133 AAA35580 L06476 AAA16974 NM_000052 NP_000043 NM_001282224 NP_001269153 NR_104109
Function May supply copper to copper-requiring proteins within the secretory pathway, when localized in the trans-Golgi network. Under conditions of elevated extracellular copper, it relocalized to the plasma membrane where it functions in the efflux of copper from cells.
Subcellular Location Isoform 5: Endoplasmic reticulum.
Tissue Specificity Found in most tissues except liver. Isoform 3 is widely expressed including in liver cell lines. Isoform 1 is expressed in fibroblasts, choriocarcinoma, colon carcinoma and neuroblastoma cell lines. Isoform 2 is expressed in fibroblasts, colon carcinoma and neuroblastoma cell lines.
Top Pathways Mineral absorption

Panoply™ Human ATP7A Knockdown Stable Cell Line - CSC-DC001196 from Creative biogene

Category Cell Line
Species Human
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