RPS3

Gene Symbol RPS3
Entrez Gene 6188
Alt Symbol S3
Species Human
Gene Type protein-coding
Description ribosomal protein S3
Other Description 40S ribosomal protein S3|IMR-90 ribosomal protein S3
Swissprots Q498B5 Q8NI95 J3KN86 B2R7N5 P23396
Accessions AAA18095 AAF82383 AAV40835 BAB79476 EAW74963 P23396 AA976344 AB062288 BAB93471 AK129794 AK130960 AK223048 BAD96768 AK313051 BAG35882 AW134501 BC003137 AAH03137 BC003577 AAH03577 BC013196 AAH13196 BC013231 BC029981 BC034149 AAH34149 BC071669 BC071917 AAH71917 BC100284 AAI00285 BC150501 AAI50502 BE797417 BM831460 BM928330 BQ645330 CB241053 D28344 BAA05710 DQ892888 ABM83814 DQ896136 ABM87135 DW448503 S42658 AAB19349 U14990 AAB60336 U14991 AAB60337 U14992 AAB60338 X55715 CAA39248 NM_001005 NP_000996 NM_001256802 NP_001243731 NM_001260506 NP_001247435 NM_001260507 NP_001247436
Function Involved in translation as a component of the 40S small ribosomal subunit (PubMed:8706699). Has endonuclease activity and plays a role in repair of damaged DNA (PubMed:7775413). Cleaves phosphodiester bonds of DNAs containing altered bases with broad specificity and cleaves supercoiled DNA more efficiently than relaxed DNA (PubMed:15707971). Displays high binding affinity for 7,8-dihydro-8-oxoguanine (8-oxoG), a common DNA lesion caused by reactive oxygen species (ROS) (PubMed:14706345). Has also been shown to bind with similar affinity to intact and damaged DNA (PubMed:18610840). Stimulates the N-glycosylase activity of the base excision protein OGG1 (PubMed:15518571). Enhances the uracil excision activity of UNG1 (PubMed:18973764). Also stimulates the cleavage of the phosphodiester backbone by APEX1 (PubMed:18973764). When located in the mitochondrion, reduces cellular ROS levels and mitochondrial DNA damage (PubMed:23911537). Has also been shown to negatively regulate DNA repair in
Subcellular Location Cytoplasm {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:17289661, ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus {ECO:0000269|PubMed:17560175, ECO:0000269|PubMed:18045535, ECO:0000269|PubMed:19460357, ECO:0000269|PubMed:20217897, ECO:0000269|PubMed:21871177}. Nucleus, nucleolus {ECO:0000269|PubMed:16314389, ECO:0000269|PubMed:19460357}. Mitochondrion inner membrane {ECO:0000269|PubMed:23911537}; Peripheral membrane protein {ECO:0000269|PubMed:23911537}. Cytoplasm, cytoskeleton, spindle {ECO:0000269|PubMed:23131551}. Note=In normal cells, located mainly in the cytoplasm with small amounts in the nucleus but translocates to the nucleus in cells undergoing apoptosis (By similarity). Nuclear translocation is induced by DNA damaging agents such as hydrogen peroxide (PubMed:17560175). Accumulates in the mitochondrion in response to increased ROS levels (PubMed:23911537). Localizes to the spindle during mitosis (
Top Pathways Ribosome

Ribosomal Protein S3 CRISPR/Cas9 KO Plasmid (h) - sc-402327 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 HDR Plasmid (h) - sc-402327-HDR from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 Double Nickase Plasmid (h) - sc-402327-NIC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 Double Nickase Plasmid (h2) - sc-402327-NIC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 CRISPR Activation Plasmid (h) - sc-402327-ACT from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 CRISPR Activation Plasmid (h2) - sc-402327-ACT-2 from Santa Cruz Biotechnology

Category CRISPR
Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 Lentiviral Activation Particles (h) - sc-402327-LAC from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 Lentiviral Activation Particles (h2) - sc-402327-LAC-2 from Santa Cruz Biotechnology

Prices $345.00
Sizes 20 µg
Species Reactivities Human

Ribosomal Protein S3 siRNA (h) - sc-96950 from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ribosomal Protein S3 shRNA Plasmid (h) - sc-96950-SH from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

Ribosomal Protein S3 shRNA (h) Lentiviral Particles - sc-96950-V from Santa Cruz Biotechnology

Category siRNA
Prices $258.00
Sizes 10 µm
Species Reactivities Human

MISSION® esiRNA - EHU105231 from Sigma-Aldrich

Category siRNA
Prices $140.00, $250.00
Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18646 from Sigma-Aldrich

Category ZFN Kit
Prices $4,999.00
Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18646 from Sigma-Aldrich

Category ZFN Kit
Prices $3,999.00
Sizes 1 kt

RPS3 siRNA (Human) - CRH4164 from Cohesion Biosciences

Category siRNA
Prices $340.00, $510.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RPS3 - MBS8210915 from MyBioSource

Prices $365.00, $515.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

Human RPS3 siRNA - orb264666 from Biorbyt

Category siRNA
Prices $485.00, $629.00
Sizes 15 nmol, 30 nmol
Species Reactivities Human

RPS3 shRNA Plasmid (Human) - CHH4164 from Cohesion Biosciences

Category siRNA
Prices $500.00, $750.00
Sizes 150 µg, 300 µg
Species Reactivities Human

RPS3 miRNA 3'UTR clone - MiUTR3H-03390 from Creative biogene

Species Reactivities Human
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