Gene Symbol | SORD |
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Entrez Gene | 6652 |
Alt Symbol | HEL-S-95n, SORD1 |
Species | Human |
Gene Type | protein-coding |
Description | sorbitol dehydrogenase |
Other Description | L-iditol 2-dehydrogenase|epididymis secretory sperm binding protein Li 95n |
Swissprots | B2R655 J3JZZ5 Q9UMD6 Q16682 Q00796 B7Z3A6 |
Accessions | AAA80566 AAB61898 EAW77284 EAW77285 Q00796 AK090738 AK295656 BAH12142 AK296574 BAG59194 AK309672 AK312444 BAG35352 BC021085 AAH21085 BC025295 AAH25295 BI258813 DA530494 DB031906 DQ892769 ABM83695 DQ896016 ABM87015 FJ224316 ACI46008 L29008 AAA80565 U07361 AAA66064 NM_003104 NP_003095 NR_034039 |
Function | Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. {ECO:0000250|UniProtKB:Q64442}. |
Subcellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}. |
Tissue Specificity | Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:19423711, ECO:0000269|PubMed:20372835}. |
Top Pathways | Pentose and glucuronate interconversions, Fructose and mannose metabolism |
Active human Sorbitol Dehydrogenase full length protein - ab167975 from Abcam
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Human Sorbitol Dehydrogenase full length protein - ab95892 from Abcam
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Sorbitol Dehydrogenase peptide (344-356) - ab45669 from Abcam
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SORD Antibody Blocking Peptide - LS-E3866 from LifeSpan Bioscience
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SORD Antibody Blocking Peptide - LS-E25812 from LifeSpan Bioscience
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SORD Antibody Blocking Peptide - LS-E22347 from LifeSpan Bioscience
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Sorbitol Dehydrogenase Recombinant Protein - H00006652-P01 from Novus Biologicals
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Sorbitol Dehydrogenase Partial Recombinant Protein - H00006652-Q01 from Novus Biologicals
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Sorbitol Dehydrogenase Recombinant Protein - H00006652-P02 from Novus Biologicals
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Recombinant Human Sorbitol Dehydrogenase Protein - NBP1-44460 from Novus Biologicals
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SORD-Antibody-Center-Blocking-Peptide - BP16049c from Abgent, a WuXi AppTec company
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Sorbitol Dehydrogenase blocking peptide - GTX89635-PEP from GeneTex
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SORD Protein (OPPA02370) - OPPA02370 from Aviva Systems Biology
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Human SORD protein - orb180413 from Biorbyt
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Human Sorbitol Dehydrogenase protein - orb90269 from Biorbyt
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SORD Blocking Peptide - 33R-1509 from Fitzgerald
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Human SORD Protein - abx060050 from Abbexa
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Sorbitol Dehydrogenase Peptide - AC21-0643-P from Abcore
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SORD (1-357, His-tag) - AR09511PU-L from Acris Antibodies
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SORD (1-357, His-tag) - AR09511PU-N from Acris Antibodies
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SORD - H00006652-P01-10 from Acris Antibodies
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SORD - H00006652-P01-25 from Acris Antibodies
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SORD - H00006652-P02 from Acris Antibodies
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SORD - H00006652-P02-10 from Acris Antibodies
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SORD - H00006652-P02-25 from Acris Antibodies
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