Gene Symbol | SORD |
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Entrez Gene | 6652 |
Alt Symbol | HEL-S-95n, SORD1 |
Species | Human |
Gene Type | protein-coding |
Description | sorbitol dehydrogenase |
Other Description | L-iditol 2-dehydrogenase|epididymis secretory sperm binding protein Li 95n |
Swissprots | B2R655 J3JZZ5 Q9UMD6 Q16682 Q00796 B7Z3A6 |
Accessions | AAA80566 AAB61898 EAW77284 EAW77285 Q00796 AK090738 AK295656 BAH12142 AK296574 BAG59194 AK309672 AK312444 BAG35352 BC021085 AAH21085 BC025295 AAH25295 BI258813 DA530494 DB031906 DQ892769 ABM83695 DQ896016 ABM87015 FJ224316 ACI46008 L29008 AAA80565 U07361 AAA66064 NM_003104 NP_003095 NR_034039 |
Function | Converts sorbitol to fructose. Part of the polyol pathway that plays an important role in sperm physiology. May play a role in the sperm motility by providing an energetic source for sperm. {ECO:0000250|UniProtKB:Q64442}. |
Subcellular Location | Mitochondrion membrane {ECO:0000250|UniProtKB:Q64442}; Peripheral membrane protein {ECO:0000250|UniProtKB:Q64442}. Cell projection, cilium, flagellum {ECO:0000250|UniProtKB:Q64442}. Note=Associated with mitochondria of the midpiece and near the plasma membrane in the principal piece of the flagellum. Also found in the epididymosome, secreted by the epididymal epithelium and that transfers proteins from the epididymal fluid to the sperm surface. {ECO:0000250|UniProtKB:Q64442}. |
Tissue Specificity | Expressed in kidney and epithelial cells of both benign and malignant prostate tissue. Expressed in epididymis (at protein level). {ECO:0000269|PubMed:16278369, ECO:0000269|PubMed:19423711, ECO:0000269|PubMed:20372835}. |
Top Pathways | Pentose and glucuronate interconversions, Fructose and mannose metabolism |
Sorbitol Dehydrogenase CRISPR/Cas9 KO Plasmid (h) - sc-405776 from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase HDR Plasmid (h) - sc-405776-HDR from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase Double Nickase Plasmid (h) - sc-405776-NIC from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase Double Nickase Plasmid (h2) - sc-405776-NIC-2 from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase CRISPR Activation Plasmid (h) - sc-405776-ACT from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase CRISPR Activation Plasmid (h2) - sc-405776-ACT-2 from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase Lentiviral Activation Particles (h) - sc-405776-LAC from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase Lentiviral Activation Particles (h2) - sc-405776-LAC-2 from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase siRNA (h) - sc-76540 from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase shRNA Plasmid (h) - sc-76540-SH from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase shRNA (h) Lentiviral Particles - sc-76540-V from Santa Cruz Biotechnology
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Sorbitol Dehydrogenase RNAi - H00006652-R01 from Novus Biologicals
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MISSION® esiRNA - EHU055671 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit - CKOZFN20339 from Sigma-Aldrich
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CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND20339 from Sigma-Aldrich
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MISSION® 3′UTR Lenti GoClone™ - HUTR08793 from Sigma-Aldrich
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SORD siRNA (Human) - CRH4532 from Cohesion Biosciences
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SORD - MBS8223279 from MyBioSource
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shRNA set against Human SORD (NM_003104.5) - SHH415176 from Creative biogene
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SORD shRNA Plasmid (Human) - CHH4532 from Cohesion Biosciences
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SORD miRNA 3'UTR clone - MiUTR3H-02123 from Creative biogene
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