ASIC2

Gene Symbol ASIC2
Entrez Gene 40
Alt Symbol ACCN, ACCN1, ASIC2a, BNC1, BNaC1, MDEG, hBNaC1
Species Human
Gene Type protein-coding
Description acid sensing (proton gated) ion channel 2
Other Description acid-sensing (proton-gated) ion channel 2|acid-sensing ion channel 2|amiloride-sensitive cation channel 1, neuronal|brain sodium channel 1|mammalian degenerin homolog|neuronal amiloride-sensitive cation channel 1
Swissprots Q16515 Q8N3E2 Q13553 Q6DJU1 E9PBX2
Accessions CCQ43074 EAW80216 Q16515 AK127748 BAG54565 AK313043 BAG35875 AL834182 CAD38879 BC075042 AAH75042 BC075043 AAH75043 EU446513 ABZ92042 U50352 AAC50432 U53212 AAC50498 U57352 AAB49182 NM_001094 NP_001085 NM_183377 NP_899233
Function Cation channel with high affinity for sodium, which is gated by extracellular protons and inhibited by the diuretic amiloride. Also permeable for Li(+) and K(+). Generates a biphasic current with a fast inactivating and a slow sustained phase. Heteromeric channel assembly seems to modulate.
Subcellular Location Cell membrane {ECO:0000250}; Multi-pass membrane protein {ECO:0000250}. Note=Localized at the plasma membrane of neurons, in the soma and punctated peripheral processes. {ECO:0000250}.
Tissue Specificity Brain and spinal cord. Isoform 1 is also detected in testis, liver, colon and ovary. {ECO:0000269|PubMed:10842183, ECO:0000269|PubMed:8631835}.
Top Pathways Taste transduction, Inflammatory mediator regulation of TRP channels

ASIC2 (E-20) - sc-22333 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
ASIC2 (E-20): sc-22333. Western blot analysis of ASIC2 expression in rat brain tissue extract.

Anti-ACCN1 antibody - ab77384 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
ICC/IF image of ab77384 stained SKNSH cells. The cells were 4% paraformaldehyde fixed (10 min) and then incubated in 1%BSA / 10% normal goat serum / 0.3M glycine in 0.1% PBS-Tween for 1h to permeabilise the cells and block non-specific protein-protein interactions. The cells were then incubated with the antibody (ab77384, 1/100 dilution) overnight at +4°C. The secondary antibody (green) was ab96899, DyLight® 488 goat anti-rabbit IgG (H+L) used at a 1/250 dilution for 1h. Alexa Fluor® 594 WGA was used to label plasma membranes (red) at a 1/200 dilution for 1h. DAPI was used to stain the cell nuclei (blue) at a concentration of 1.43µM.

Anti-ACCN1 antibody - ab42635 from Abcam

Prices $370.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
All lanes : Anti-ACCN1 antibody (ab42635) at 2 µg/mlLane 1 : MarkerLane 2 : HepG2 Cell Lysate

Anti-ACCN1 antibody [EPR11029] - ab169768 from Abcam

Prices $357.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EPR11029
All lanes : Anti-ACCN1 antibody [EPR11029] (ab169768) at 1/1000 dilutionLane 1 : Human fetal kidney lysateLane 2 : Human glioma lysateLysates/proteins at 10 µg per lane.SecondaryHRP labeled goat anti-rabbit at 1/2000 dilution

Anti-SV40 T-antigen antibody [LP7N] - ab43234 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone LP7N

Anti-SV40 T-antigen antibody [Pab 416] - ab20248 from Abcam

Prices $395.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone Pab 416

Anti-SV40 T-antigen antibody [Pab 430] - ab20249 from Abcam

Prices $370.00
Sizes 50 µg
Host Mouse
Clonality Monoclonal
Clone Pab 430

Anti-SV40 T-antigen antibody [PAB108] - ab78146 from Abcam

Prices $372.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone PAB108

Anti-ACCN1 / ASIC2 Antibody (aa127-156) - LS-C155921 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Formalin-fixed and paraffin-embedded human brain tissue reacted with ACCN1 Antibody , which was peroxidase-conjugated to the secondary antibody, followed by DAB staining. This data demonstrates the use of this antibody for immunohistochemistry; clinical relevance has not been evaluated.

Anti-ACCN1 / ASIC2 Antibody (aa481-530) IHC-plus™ - LS-B156 from LifeSpan Bioscience

Prices $450.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-ACCN1 antibody IHC of human brain, cortex. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B156 concentration 5 ug/ml.

Anti-ACCN1 / ASIC2 Antibody (aa2-18) - LS-C11721 from LifeSpan Bioscience

Prices $465.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (N-Terminus) - LS-C34819 from LifeSpan Bioscience

Prices $385.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody - LS-C63503 from LifeSpan Bioscience

Prices $575.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa470-503) - LS-C93912 from LifeSpan Bioscience

Prices $325.00
Sizes 500 µg
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa120-148, AP) - LS-C250648 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa120-148, APC) - LS-C250649 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa120-148, PE) - LS-C250653 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa120-148, Azide-free, HRP) - LS-C250652 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa120-148, FITC) - LS-C250651 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa127-156) - LS-C319274 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (aa120-148, Biotin) - LS-C250650 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-ACCN1 / ASIC2 Antibody (C-Terminus) - LS-C110053 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ACCN1 antibody LS-C110053 Western blot of THP-1 cell lysate.

Anti-ACCN1 / ASIC2 Antibody (aa15-26) IHC-plus™ - LS-B4761 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µl
Host Rabbit
Clonality Polyclonal
Anti-ACCN1 antibody IHC of human cerebellum. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B4761 concentration 2.5 ug/ml.

ACCN1 Antibody - NBP1-20093 from Novus Biologicals

Prices $329.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal

ACCN1 Antibody - NBP2-14321 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Immunohistochemistry-Paraffin: ACCN1 Antibody [NBP2-14321] - Staining of human hippocampus shows distinct positivity in neuropil along with subsets of neuronal cells.
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