SHH

Gene Symbol SHH
Entrez Gene 6469
Alt Symbol HHG1, HLP3, HPE3, MCOPCB5, SMMCI, TPT, TPTPS
Species Human
Gene Type protein-coding
Description sonic hedgehog
Other Description sonic hedgehog homolog|sonic hedgehog protein
Swissprots A4D247 Q15465 Q75MC9
Accessions AAB67604 AAQ87879 AAS01990 ADL14518 BAA34689 EAL23913 EAX04543 Q15465 AY927450 AY927451 AY927452 AY927453 AY927455 BC111925 AAI11926 L38518 AAA62179 XM_011516479 XP_011514781 XM_011516480 XP_011514782 XM_011516481 XP_011514783 XM_011516482 XP_011514784 NM_000193 NP_000184
Function Intercellular signal essential for a variety of patterning events during development: signal produced by the notochord that induces ventral cell fate in the neural tube and somites, and the polarizing signal for patterning of the anterior- posterior axis of the developing limb bud. Displays both floor plate- and motor neuron-inducing activity. The threshold concentration of N-product required for motor neuron induction is 5-fold lower than that required for floor plate induction. Activates the transcription of target genes by interacting with its receptor PTCH1 to prevent normal inhibition by PTCH1 on the constitutive signaling activity of SMO (By similarity). {ECO:0000250}.
Subcellular Location Sonic hedgehog protein C-product: Secreted, extracellular space {ECO:0000250}. Note=The C-terminal peptide diffuses from the cell. {ECO:0000250}.
Tissue Specificity Expressed in fetal intestine, liver, lung, and kidney. Not expressed in adult tissues.
Top Pathways Hedgehog signaling pathway, Basal cell carcinoma

Shh Antibody - 2287 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from 293 cells and 293 cells transiently transfected with mouse Shh construct, using Shh antibody.

Shh/Ihh Antibody - 2271 from Cell Signaling Technology

Prices $246.00
Sizes 100 µl (10 western blots)
Host Rabbit
Clonality Polyclonal
Western blot analysis of total cell lysates from 293 cells and 293 cells transiently transfected with mouse Shh or Ihh construct, using Shh/Ihh Antibody.

Shh (C9C5) Rabbit mAb - 2207 from Cell Signaling Technology

Prices $99.00, $246.00
Sizes 20 µl (2 western blots), 100 µl (10 western blots)
Host Rabbit
Clonality Monoclonal
Clone C9C5
Western blot analysis of extracts from HT29 and GH3 cells, and GH3 cell conditioned medium (CM), using Shh (C9C5) Rabbit mAb.

Shh (G-20) - sc-33943 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Shh (E-1) - sc-365112 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
Shh (E-1): sc-365112. Immunofluorescence staining of methanol-fixed HeLa cells showing cytoplasmic localization.

Shh (H-160) - sc-9024 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Shh (H-160): sc-9024. Western blot analysis of recombinant N-terminal domain Shh.

Shh (C-12) - sc-33942 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Shh (N-19) - sc-1194 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
Shh (N-19): sc-1194. Western blot analysis and detection of Shh precursor in IMR-32 whole cell lysate.

Shh (C-18) - sc-1195 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Anti-Sonic Hedgehog antibody - ab19897 from Abcam

Prices $379.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Standard Curve for Sonic Hedgehog (Analyte: Sonic Hedgehog protein (Amino end active) (ab63216)); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [10H6] to Sonic Hedgehog (ab87382) at 1µg/ml and Detector Antibody Rabbit polyclonal to Sonic Hedgehog (ab19897) at 0.5µg/ml.

Anti-Sonic Hedgehog antibody - ab73958 from Abcam

Prices $382.00
Sizes 500 µl
Host Rabbit
Clonality Polyclonal
Human lung tissue stained with ab73958 at 1/100 dilution for 30 mins at RT. Tissue sections boiled in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Anti-Sonic Hedgehog antibody - ab114122 from Abcam

Prices $376.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-Sonic Hedgehog antibody (ab114122) at 1 µg/mlLane 1 : E10 Mouse Embryo Brain Tissue LysateLane 2 : Mouse Embryo E10 Tissue LysateLane 3 : E12 Mouse Embryo Brain and Spinal Cord Tissue LysateLane 4 : E14 Mouse Embryo Brain Tissue LysateLane 5 : E14 Ms Embryo Spinal Cord Tissue LysateLane 6 : E16 Ms Embryo Brain Tissue LysateLysates/proteins at 10 µg per lane.SecondaryGoat Anti-Rabbit IgG H&L (HRP) preadsorbed (ab97080) at 1/5000 dilutiondeveloped using the ECL techniquePerformed under reducing conditions.

Anti-Sonic Hedgehog antibody [10H6] - ab87382 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 10H6
Standard Curve for Sonic Hedgehog (Analyte: Sonic Hedgehog protein (Amino end active) (ab63216)); dilution range 1pg/ml to 1µg/ml using Capture Antibody Mouse monoclonal [10H6] to Sonic Hedgehog (ab87382) at 1µg/ml and Detector Antibody Rabbit polyclonal to Sonic Hedgehog (ab19897) at 0.5µg/ml.

Anti-Sonic Hedgehog antibody [171018] - ab50515 from Abcam

Prices $384.00
Sizes 125 µg
Host Rat
Clonality Monoclonal
Clone 171018
ab50515 staining Sonic Hedgehog in human Panc-1 cells by immunocytochemistry/ immunofluorescence. Cells were paraformaldehyde fixed prior to blocking in 3% BSA for 30 minutes at 24°C. The primary antibody was used at 25 μg/ml and incubated with the sample for 16 hours at 4°C. Alexa fluor® 488 donkey polyclonal to rat Ig, diluted 1/700, was used as the secondary antibody.See Abreview

Anti-Sonic Hedgehog antibody [3A2] - ab195442 from Abcam

Prices $376.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 3A2
Anti-Sonic Hedgehog antibody [3A2] (ab195442) at 1/2000 dilution + HEK-293T cell lysates, transfected with Human Sonic Hedgehog expression vector

Anti-Sonic Hedgehog antibody [5H4] - ab135240 from Abcam

Prices $384.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone 5H4
Anti-Sonic Hedgehog antibody [5H4] (ab135240) at 1/500 dilution + Human Sonic Hedgehog recombinant protein

Anti-Sonic Hedgehog antibody [EP1190Y] - ab53281 from Abcam

Prices $394.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal
Clone EP1190Y
Immunofluorescent staining of HepG2 using anti-Sonic Hedgehog Protein Alexa Fluor 555 RabMAB

Anti-Sonic Hedgehog antibody [MM0240-2G19] - ab135207 from Abcam

Prices $370.00
Sizes 100 µg
Host Rat
Clonality Monoclonal
Clone MM0240-2G19

Anti-Sonic Hedgehog antibody, prediluted - ab73959 from Abcam

Prices $376.00
Sizes 7 ml
Host Rabbit
Clonality Polyclonal
human lung lysate stained with ab73959 (as supplied) for 30 min at RT. Tissue sections boiled in 10mM citrate buffer, pH 6.0 for 10 min followed by cooling at RT for 20 min.

Anti-Sonic Hedgehog antibody [SH154] - ab50611 from Abcam

Prices $370.00
Sizes 100 µl
Host Mouse
Clonality Monoclonal
Clone SH154

Anti-SHH / Sonic Hedgehog Antibody (aa203-218) - LS-C343862 from LifeSpan Bioscience

Prices $305.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Sonic Hedgehog antibody IHC-paraffin: Human Mammary Tissue.

Anti-SHH / Sonic Hedgehog Antibody (aa199-437) - LS-C10144 from LifeSpan Bioscience

Prices $325.00
Sizes 100 µg
Host Rat
Clonality Monoclonal

Anti-SHH / Sonic Hedgehog Antibody (Glu53) - LS-C75801 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µl
Host Rabbit
Clonality Monoclonal

Anti-SHH / Sonic Hedgehog Antibody (N-Terminus) - LS-C122424 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SHH / Sonic Hedgehog Antibody - LS-C132078 from LifeSpan Bioscience

Prices $575.00
Sizes 500 µg
Host Rat
Clonality Monoclonal
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