DIABLO

Gene Symbol	DIABLO
Entrez Gene	56616
Alt Symbol	DFNA64, SMAC
Species	Human
Gene Type	protein-coding
Description	diablo, IAP-binding mitochondrial protein
Other Description	diablo homolog, mitochondrial|direct IAP-binding protein with low pI|second mitochondria-derived activator of caspase
Swissprots	Q9HAV6 Q9BT11 B2RDQ0 Q6W3F3 Q96LV0 Q9NR28
Accessions	EAW98311 EAW98312 EAW98313 EAW98314 EAW98315 EAW98316 Q9NR28 AF262240 AAF87716 AF298770 AAG22077 AK001399 BAG50903 AK024768 BAB14994 AK057778 BAB71568 AK222664 BAD96384 AK315629 BAG37997 AY313210 AAQ86939 BC004417 AAH04417 BC011909 AAH11909 BC046209 BC095468 AAH95468 BF313712 BF724951 BM746689 CD742753 CF128595 DA877400 DA910387 DA915183 DB254800 DQ893061 ABM83987 DQ896313 ABM87312 JX679472 AFX61342 N66735 NM_001278302 NP_001265231 NM_001278303 NP_001265232 NM_001278304 NP_001265233 NM_001278342 NP_001265271 NM_019887 NP_063940 NM_138930 NP_620308 NM_138929
Function	Promotes apoptosis by activating caspases in the cytochrome c/Apaf-1/caspase-9 pathway. Acts by opposing the inhibitory activity of inhibitor of apoptosis proteins (IAP). Inhibits the activity of BIRC6/bruce by inhibiting its binding to caspases. Isoform 3 attenuates the stability and apoptosis- inhibiting activity of XIAP/BIRC4 by promoting XIAP/BIRC4 ubiquitination and degradation through the ubiquitin-proteasome pathway. Isoform 3 also disrupts XIAP/BIRC4 interacting with processed caspase-9 and promotes caspase-3 activation. Isoform 1 is defective in the capacity to down-regulate the XIAP/BIRC4 abundance. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016, ECO:0000269|PubMed:15200957}.
Subcellular Location	Mitochondrion {ECO:0000269|PubMed:14523016}. Note=Released into the cytosol when cells undergo apoptosis.
Tissue Specificity	Ubiquitously expressed with highest expression in testis. Expression is also high in heart, liver, kidney, spleen, prostate and ovary. Low in brain, lung, thymus and peripheral blood leukocytes. Isoform 3 is ubiquitously expressed. {ECO:0000269|PubMed:10929711, ECO:0000269|PubMed:14523016}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SMAC Human ELISA Kit - ab155439 from Abcam Category ELISA Kit Prices $499.00 Sizes 1 x 96 tests Sensitivity < 0.1 ng/ml Range 0.12 ng/ml - 30 ng/ml

Human DIABLO / SMAC ELISA Kit (Sandwich ELISA) - LS-F2710 from LifeSpan Bioscience Category ELISA Kit Prices $530.00 Sizes 1 plate Sensitivity 10 pg/ml Range 0.123-12 ng/ml

Human DIABLO / SMAC ELISA Kit (Sandwich ELISA) - LS-F186 from LifeSpan Bioscience Category ELISA Kit Prices $620.00, $1,090.00, $2,380.00 Sizes 1 plate, 2 plate, 5 plate Sensitivity 0.123 ng/ml Range 0.123-12 ng/ml

Human DIABLO / SMAC ELISA Kit (Sandwich ELISA) - LS-F9667 from LifeSpan Bioscience Category ELISA Kit Prices $720.00 Sizes 1 plate Sensitivity 0.056 ng/ml Range 0.123-12 ng/ml

Human SMAC ELISA Kit - RAB0142 from Sigma-Aldrich Category ELISA Kit Prices $608.00 Sizes 1 kt

Human Total SMAC/Diablo DuoSet IC ELISA - DYC789-2 from R&D Systems Category ELISA Kit Prices $329.00 Sizes 1 kit (for 2 Plates) Range 62.50 - 4,000 pg/mL

Human Diablo ELISA Kit - orb170145 from Biorbyt Category ELISA Kit Prices $570.00 Sizes 96 well Sensitivity < 10 pg/ml Range 31.2 pg/ml-2000 pg/ml

Diablo homolog, mitochondrial (DIABLO), Human, ELISA Kit - CSB-EL006888HU from ARP American Research Products Category ELISA Kit Prices $495.00, $695.00, $696.00, $699.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Human SMAC ELISA - ELH-SMAC from RayBiotech Category ELISA Kit Prices $560.00, $1,008.00, $2,241.00 Sizes 1 plate kit, 2 plate kit, 5 plate kit Sensitivity 100 pg/ml Range 0.1 ng/ml - 30 ng/ml

Human Smac ELISA Kit - HS0020 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine Smac/DIABLO ELISA Kit - AS0020 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Human SMAC ELISA Kit - DEIA5779 from Creative Diagnostics Category ELISA Kit Sensitivity The minimum detectable dose of SMAC is typically less than 0.1 ng/mL.

Diablo Homolog (DIABLO), ELISA Kit - MBS2000013 from MyBioSource Category ELISA Kit Prices $380.00, $565.00, $765.00, $3,130.00, $5,670.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.058ng/mL. Range 0.156-10ng/mL

Diablo Homolog (DIABLO), ELISA Kit - MBS2024949 from MyBioSource Category ELISA Kit Prices $405.00, $605.00, $820.00, $3,375.00, $6,125.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.063ng/mL. Range 0.156-10ng/mL

diablo homolog (Drosophila) , ELISA Kit - MBS938802 from MyBioSource Category ELISA Kit Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00 Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Diablo/SMAC, ELISA Kit - MBS177134 from MyBioSource Category ELISA Kit Prices $425.00 Sizes 1x96 wells Sensitivity < 10pg/ml Range 31.2pg/ml-2000pg/ml

Second mitochondrial-derived activator of caspase, ELISA Kit - MBS740875 from MyBioSource Category ELISA Kit Prices $470.00, $675.00, $2,925.00, $5,490.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 1.0 ng/mL.

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS041488 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS104727 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS038940 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS029743 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS023091 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS026676 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS032569 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Second Mitochondrial-Derived Activator of Caspase, ELISA Kit - MBS053317 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

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