Prkdc

Gene Symbol	Prkdc
Entrez Gene	19090
Alt Symbol	AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
Species	Mouse
Gene Type	protein-coding
Description	protein kinase, DNA activated, catalytic polypeptide
Other Description	DNA-PK catalytic subunit|DNA-dependent protein kinase catalytic subunit|doxorubicin nephropathy|severe combined immunodeficiency
Swissprots	O88187 P97313 P97928 Q3V2W8 Q9Z341 Q307W9 E9QN15 Q8C2A7
Accessions	BAB91149 CAC42768 CAC42769 CAC42770 CAC42771 EDK97403 P97313 AB007544 BAA28873 AB011543 BAA28875 AK084827 BAE43387 AK088981 BAC40685 AK137732 AU019811 BC028664 D83786 BAA12115 D87521 BAA19566 DQ235257 ABB36568 DQ235258 ABB36569 U78157 AAB36939 U78158 AAB36940 XM_006521861 XP_006521924 XM_011245841 XP_011244143 XM_011245842 XP_011244144 NM_011159 NP_035289
Function	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat
Subcellular Location	Nucleus. Nucleus, nucleolus {ECO:0000250}.
Top Pathways	Cell cycle, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC), Mouse, ELISA Kit - SEK362Mu from ARP American Research Products Category ELISA Kit Prices $740.00 Sizes 96 t Sensitivity 0.105ng/mL Range 0.312-20ng/mL

ELISA Kit for Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) - SEK362Mu from Cloud-clone Category ELISA Kit Sensitivity The minimum detectable dose of this kit is typically less than 0.105ng/mL. Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC), ELISA Kit - MBS9307461 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC), ELISA Kit - MBS2019433 from MyBioSource Category ELISA Kit Prices $385.00, $575.00, $785.00, $3,210.00, $5,825.00 Sizes 24 -strip-wells, 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity Typically less than 0.105ng/mL. Range 0.313-20ng/mL

Mouse PRKDC ELISA Kit - abx154574 from Abbexa Category ELISA Kit Sensitivity 0.105 ng/ml Range 0.313 ng/ml - 20 ng/ml

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC), Mouse, ELISA Kit - DL-PRKDC-Mu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Range 0.312-20 ng/mL

Mouse PRKDC ELISA Kit - orb369587 from Biorbyt Category ELISA Kit Prices $561.00, $638.00 Sizes 48 test, 96 test Range Detection Range: 0.313-20ng/mL Detection low threshold: 0.105ng/mL

Mouse PRKDC ELISA Kit - abx572766 from Abbexa Category ELISA Kit Sensitivity 0.105 ng/ml Range 0.313 ng/ml - 20 ng/ml

Mouse Prkdc ELISA Kit - E065202 from Biobool Category ELISA Kit

PRKDC ELISA Kit (Mouse) (OKCD01065) - OKCD01065 from Aviva Systems Biology Category ELISA Kit Prices $555.00 Sizes 96 wells Sensitivity < 0.105 ng/mL Range 0.312-20 ng/mL

Mouse DNA-dependent protein kinase catalytic subunit (PRKDC) ELISA Kit - AE25929MO from ARP American Research Products Category ELISA Kit Prices $549.00 Sizes 96 t Sensitivity 0.105 ng/mL Range 0.312-20 ng/mL

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC), ELISA Kit - MBS450443 from MyBioSource Category ELISA Kit Prices $425.00, $560.00, $2,480.00, $4,820.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity <0.105ng/mL Range 0.312-20ng/mL

Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC), ELISA Kit - MBS9372243 from MyBioSource Category ELISA Kit Prices $435.00, $600.00, $2,650.00, $5,205.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells

Search more