Prkdc

Gene Symbol	Prkdc
Entrez Gene	19090
Alt Symbol	AI326420, AU019811, DNA-PKcs, DNAPDcs, DNAPK, DNPK1, DOXNPH, HYRC1, XRCC7, dxnph, p460, scid, slip
Species	Mouse
Gene Type	protein-coding
Description	protein kinase, DNA activated, catalytic polypeptide
Other Description	DNA-PK catalytic subunit|DNA-dependent protein kinase catalytic subunit|doxorubicin nephropathy|severe combined immunodeficiency
Swissprots	O88187 P97313 P97928 Q3V2W8 Q9Z341 Q307W9 E9QN15 Q8C2A7
Accessions	BAB91149 CAC42768 CAC42769 CAC42770 CAC42771 EDK97403 P97313 AB007544 BAA28873 AB011543 BAA28875 AK084827 BAE43387 AK088981 BAC40685 AK137732 AU019811 BC028664 D83786 BAA12115 D87521 BAA19566 DQ235257 ABB36568 DQ235258 ABB36569 U78157 AAB36939 U78158 AAB36940 XM_006521861 XP_006521924 XM_011245841 XP_011244143 XM_011245842 XP_011244144 NM_011159 NP_035289
Function	Serine/threonine-protein kinase that acts as a molecular sensor for DNA damage. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break (DSB) repair and V(D)J recombination. Must be bound to DNA to express its catalytic properties. Promotes processing of hairpin DNA structures in V(D)J recombination by activation of the hairpin endonuclease artemis (DCLRE1C). The assembly of the DNA-PK complex at DNA ends is also required for the NHEJ ligation step. Required to protect and align broken ends of DNA. May also act as a scaffold protein to aid the localization of DNA repair proteins to the site of damage. Found at the ends of chromosomes, suggesting a further role in the maintenance of telomeric stability and the prevention of chromosomal end fusion. Also involved in modulation of transcription. Recognizes the substrate consensus sequence [ST]-Q. Phosphorylates 'Ser-139' of histone variant H2AX/H2AFX, thereby regulating DNA damage response mechanism. Phosphorylat
Subcellular Location	Nucleus. Nucleus, nucleolus {ECO:0000250}.
Top Pathways	Cell cycle, Non-homologous end-joining

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Mouse PRKDC protein - orb244459 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Mouse

Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) - RPK362Mu01 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Protein Kinase, DNA Activated, Catalytic Polypeptide (PRKDC) - RPK362Mu02 from Cloud-clone Category Protein Source E.coli Species Mouse

Recombinant Mouse DNA-dependent protein kinase catalytic subunit(Prkdc) ,partial - CSB-YP018714MO CSB-BP018714MO CSB-MP018714MO from Cusabio Category Protein Source Yeast or Baculovirus or Mammalian cell Species Mouse

Recombinant mouse DNA-dependent protein kinase catalytic subunit - CSB-EP018714MO from Cusabio Category Protein Source E.coli Species Mouse

Recombinant Mouse PRKDC Protein - PRKDC-13375M from Creative Biomart Category Protein Source Mammalian Cells Species Mouse

PRKDC Recombinant Protein (OPCD00862) - OPCD00862 from Aviva Systems Biology Category Protein Source E.coli Species Mouse

Recombinant mouse DNA-dependent protein kinase catalytic subunit - AP70661 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E.coli Species Mouse

DNA-dependent protein kinase catalytic subunit, Recombinant Protein - MBS956945 from MyBioSource Category Protein Prices $185.00, $420.00, $680.00, $1,070.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 1 mg (E-Coli) Source E Coli or Yeast or Baculovirus or Mammalian Cell

DNA-dependent protein kinase catalytic subunit, Recombinant Protein - MBS9420563 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source E Coli Species Mouse

Protein Kinase, DNA Activated, Catalytic Polypeptide, Recombinant Protein - MBS2033257 from MyBioSource Category Protein Prices $175.00, $360.00, $560.00 Sizes 10 µg, 50 µg, 100 µg Source Prokaryotic expression Species Mouse

Search more