| Gene Symbol |
KCND2
|
| Entrez Gene |
3751
|
| Alt Symbol |
KV4.2, RK5
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
potassium channel, voltage gated Shal related subfamily D, member 2
|
| Other Description |
potassium voltage-gated channel subfamily D member 2|potassium voltage-gated channel, Shal-related subfamily, member 2|voltage-gated potassium channel subunit Kv4.2|voltage-sensitive potassium channel
|
| Swissprots |
Q9NZV8 O95012 O95021 Q9UNH9 Q9UBY7 Q9UN98 Q2TBD3
|
| Accessions |
AAC83405 AAD52159 AAF65618 AAS07530 EAL24350 EAW83541 Q9NZV8 AB028967 BAA82996 AF121104 AAD22053 AJ010969 CAB56841 AK307139 BC110449 AAI10450 BC110450 AAI10451 XM_005250322 XP_005250379 XM_011516165 XP_011514467 XM_011516166 XP_011514468 XM_011516167 XP_011514469 NM_012281 NP_036413
|
| Function |
Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhytm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By
|
| Subcellular Location |
Cell membrane {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166}; Multi-pass membrane protein {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:14980201, ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:11102480}. Cell junction, synapse {ECO:0000250|UniProtKB:Q63881}. Perikaryon {ECO:0000250|UniProtKB:Q63881}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q63881}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q63881}. Cell junction {ECO:0000250|UniProtKB:Q63881}. Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detecte
|
| Tissue Specificity |
Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204). {ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:12395204, ECO:0000269|PubMed:15991246}.
|