KCND2

Gene Symbol	KCND2
Entrez Gene	3751
Alt Symbol	KV4.2, RK5
Species	Human
Gene Type	protein-coding
Description	potassium channel, voltage gated Shal related subfamily D, member 2
Other Description	potassium voltage-gated channel subfamily D member 2|potassium voltage-gated channel, Shal-related subfamily, member 2|voltage-gated potassium channel subunit Kv4.2|voltage-sensitive potassium channel
Swissprots	Q9NZV8 O95012 O95021 Q9UNH9 Q9UBY7 Q9UN98 Q2TBD3
Accessions	AAC83405 AAD52159 AAF65618 AAS07530 EAL24350 EAW83541 Q9NZV8 AB028967 BAA82996 AF121104 AAD22053 AJ010969 CAB56841 AK307139 BC110449 AAI10450 BC110450 AAI10451 XM_005250322 XP_005250379 XM_011516165 XP_011514467 XM_011516166 XP_011514468 XM_011516167 XP_011514469 NM_012281 NP_036413
Function	Voltage-gated potassium channel that mediates transmembrane potassium transport in excitable membranes, primarily in the brain. Mediates the major part of the dendritic A-type current I(SA) in brain neurons (By similarity). This current is activated at membrane potentials that are below the threshold for action potentials. It regulates neuronal excitability, prolongs the latency before the first spike in a series of action potentials, regulates the frequency of repetitive action potential firing, shortens the duration of action potentials and regulates the back-propagation of action potentials from the neuronal cell body to the dendrites. Contributes to the regulation of the circadian rhytm of action potential firing in suprachiasmatic nucleus neurons, which regulates the circadian rhythm of locomotor activity (By similarity). Functions downstream of the metabotropic glutamate receptor GRM5 and plays a role in neuronal excitability and in nociception mediated by activation of GRM5 (By
Subcellular Location	Cell membrane {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:11507158, ECO:0000269|PubMed:14623880, ECO:0000269|PubMed:14695263, ECO:0000269|PubMed:14980201, ECO:0000269|PubMed:15454437, ECO:0000269|PubMed:16934482, ECO:0000269|PubMed:19171772, ECO:0000269|PubMed:24501278, ECO:0000269|PubMed:24811166}; Multi-pass membrane protein {ECO:0000269|PubMed:11102480, ECO:0000269|PubMed:14980201, ECO:0000305}. Cell projection, dendrite {ECO:0000269|PubMed:11102480}. Cell junction, synapse {ECO:0000250|UniProtKB:Q63881}. Perikaryon {ECO:0000250|UniProtKB:Q63881}. Cell junction, synapse, postsynaptic cell membrane {ECO:0000250|UniProtKB:Q63881}. Cell projection, dendritic spine {ECO:0000250|UniProtKB:Q63881}. Cell junction {ECO:0000250|UniProtKB:Q63881}. Note=In neurons, primarily detected on dendrites, dendritic spines and on the neuron cell body, but not on axons. Localized preferentially at the dendrites of pyramidal cells in the hippocampus CA1 layer. Detected at GABAergic synapses. Detecte
Tissue Specificity	Detected in ovary, in corpus luteum and in granulosa and theca cells in the follicle (at protein level) (PubMed:15991246). Highly expressed throughout the brain (PubMed:10551270, PubMed:10729221). Detected in amygdala, caudate nucleus, cerebellum, hippocampus, substantia nigra and thalamus (PubMed:10551270, PubMed:10729221). Expression is not detectable or very low in heart, kidney, liver, lung, pancreas and skeletal muscle (PubMed:10551270, PubMed:10729221). Not detectable in human heart atrium (PubMed:12395204). {ECO:0000269|PubMed:10551270, ECO:0000269|PubMed:10729221, ECO:0000269|PubMed:12395204, ECO:0000269|PubMed:15991246}.

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

KCND2 / Kv4.2 Antibody Blocking Peptide - LS-E3629 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCND2 / Kv4.2 Antibody Blocking Peptide - LS-E12525 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

KCND2-Antibody-N-term-Blocking-Peptide - BP14832a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Recombinant human Potassium voltage-gated channel subfamily D member 2 (OPCA01263) - OPCA01263 from Aviva Systems Biology Category Protein Prices $220.00 Sizes 50 µg Species Human

Human KCND2 protein - orb245894 from Biorbyt Category Protein Prices $340.00, $629.00, $1,003.00, $1,556.00 Sizes 50 μg, 200 μg, 500 μg, 1 mg Species Human

KCND2 Blocking Peptide - 33R-7976 from Fitzgerald Category Peptide Prices $130.00 Sizes 100 µg

KCND2 fusion protein - Ag15879 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

KCND2 fusion protein - Ag16572 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PET28a Species Human

Recombinant Human KCND2, GST-tagged - KCND2-237H from Creative Biomart Category Protein Source E.coli Species Human

Recombinant human Potassium voltage-gated channel subfamily D member 2 - CSB-EP012023HU CSB-BP012023HU CSB-MP012023HU from Cusabio Category Protein Source E.coli or Baculovirus or Mammalian cell Species Human

Recombinant human Potassium voltage-gated channel subfamily D member 2 - CSB-YP012023HU from Cusabio Category Protein Source Yeast Species Human

Potassium voltage-gated channel subfamily D member 2 - RPC141028 from Biomatik Category Protein Prices $299.20, $352.00, $550.00, $687.50, $997.50, $1,507.50 Sizes 10 µg, 50 µg, 100 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

Potassium voltage-gated channel subfamily D member 2 , Recombinant Protein - MBS1265126 from MyBioSource Category Protein Prices $190.00, $460.00, $750.00, $815.00, $1,180.00, $1,290.00 Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 500 µg (Yeast), 1 mg (E-Coli), 1 mg (Yeast) Source E Coli or Yeast or Baculovirus or Mammalian Cell

Kv4.2 Recombinant Protein Antigen - NBP1-87708PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

KCND2 Peptide, Human - M34GP07937H from Creative Peptides Category Peptide Source Synthetic. Species Human

Recombinant human Potassium voltage-gated channel subfamily D member 2 - AP72633 from Signalway Antibody Category Protein Prices $260.00, $735.00, $1,240.00, $1,975.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

Potassium voltage-gated channel subfamily D member 2, Recombinant Protein - MBS9422358 from MyBioSource Category Protein Prices $280.00, $665.00, $1,080.00, $1,690.00 Sizes 50 µg, 200 µg, 500 µg, 1 mg Source Yeast Species Human

Potassium voltage-gated channel subfamily D member 2 (KCND2), Recombinant Protein - MBS7017639 from MyBioSource Category Protein Prices $1,420.00, $2,405.00, $3,615.00 Sizes 10 µg, 50 µg, 100 µg Source Cell Free Expression Species Human

Recombinant Human KCND2 Protein (406-630 aa), His-tagged - KCND2-1430H from Creative Biomart Category Protein Source Yeast Species Human

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