| Gene Symbol |
FOXA2
|
| Entrez Gene |
3170
|
| Alt Symbol |
HNF3B, TCF3B
|
| Species |
Human
|
| Gene Type |
protein-coding
|
| Description |
forkhead box A2
|
| Other Description |
HNF-3-beta|HNF-3B|TCF-3B|forkhead box protein A2|hepatic nuclear factor-3-beta|hepatocyte nuclear factor 3, beta|hepatocyte nuclear factor 3-beta|transcription factor 3B
|
| Swissprots |
Q8WUW4 Q96DF7 Q9Y261
|
| Accessions |
AAD41081 AAD51978 ACA06111 CAJ01277 CAJ01278 EAX10174 EAX10175 Q9Y261 AA469087 AB028021 BAA78106 AI268650 AI302734 AK301611 BAG63097 BC006545 AAH06545 BC011780 AAH11780 BC019288 AAH19288 BM273279 BQ643619 DQ892883 ABM83809 DQ896132 ABM87131 XM_006723562 XP_006723625 XM_011529231 XP_011527533 NM_021784 NP_068556 NM_153675 NP_710141
|
| Function |
Transcription factor that is involved in embryonic development, establishment of tissue-specific gene expression and regulation of gene expression in differentiated tissues. Is thought to act as a 'pioneer' factor opening the compacted chromatin for other proteins through interactions with nucleosomal core histones and thereby replacing linker histones at target enhancer and/or promoter sites. Binds DNA with the consensus sequence 5'-[AC]A[AT]T[AG]TT[GT][AG][CT]T[CT]-3' (By similarity). In embryonic development is required for notochord formation. Involved in the development of multiple endoderm-derived organ systems such as the liver, pancreas and lungs; FOXA1 and FOXA2 seem to have at least in part redundant roles. Originally described as a transcription activator for a number of liver genes such as AFP, albumin, tyrosine aminotransferase, PEPCK, etc. Interacts with the cis-acting regulatory regions of these genes. Involved in glucose homeostasis; regulates the expression of genes im
|
| Subcellular Location |
Nucleus {ECO:0000255|PROSITE- ProRule:PRU00089, ECO:0000269|PubMed:14500912}. Cytoplasm {ECO:0000269|PubMed:14500912}. Note=Shuttles between the nucleus and cytoplasm in a CRM1-dependent manner; in response to insulin signaling via AKT1 is exported from the nucleus.
|
| Top Pathways |
Maturity onset diabetes of the young
|
![Western Blot: FOXA2 Overexpression Lysate (Adult Normal) [NBL1-10799] - Left - Empty vector transfected control cell lysate (HEK293 cell lysate); Right - Over-expression Lysate for FOXA2.](http://www.bioprodhub.com/system/product_images/cel_products/5/sub_2/3494_FOXA2-Overexpression-Lysate-(Adult-Normal)-Western-Blot-NBL1-10799-img0003.jpg)