Prom1

Gene Symbol	Prom1
Entrez Gene	19126
Alt Symbol	4932416E19Rik, AC133, CD133, Prom, Prom-1, Proml1
Species	Mouse
Gene Type	protein-coding
Description	prominin 1
Other Description	antigen AC133 homolog|prominin-1|prominin-like 1|prominin-like protein 1
Swissprots	Q80XB6 Q80XB2 O54990 Q80XB3 O35408 Q8BH12
Accessions	EDL37600 EDL37601 EDL37602 EDL37603 EDL37604 EDL37605 EDL37606 O54990 AF026269 AAB86715 AF039663 AAB96916 AF305215 AAO11840 AK029921 BAC26678 AK030027 BAC26745 AK085654 BAC39496 AY099088 AAM28245 AY223521 AAO72429 AY223522 AAO72430 BC028286 AAH28286 CJ054003 CX224587 EH108160 XM_006503786 XP_006503849 XM_006503788 XP_006503851 XM_006503789 XP_006503852 XM_006503790 XP_006503853 XM_006503791 XP_006503854 XM_011240703 XP_011239005 XM_011240704 XP_011239006 XM_011240705 XP_011239007 XM_011240706 XP_011239008 XM_011240707 XP_011239009 NM_001163577 NP_001157049 NM_001163578 NP_001157050 NM_001163581 NP_001157053 NM_001163582 NP_001157054 NM_001163583 NP_001157055 NM_001163584 NP_001157056 NM_001163585 NP_001157057 NM_008935 NP_032961
Function	May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. {ECO:0000269|PubMed:19228982}.
Subcellular Location	Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Found in extracellular membrane particles in various body fluids such as ventricular fluid of the developing brain and urine.
Tissue Specificity	In the submandibular gland, expressed on the apical side of epithelial cells. In the parotid gland, expressed in the intercalated ducts. In the sublingual gland, expressed in intercalated ducts. In the extraorbital lacrimal gland, expressed in the intercalated tubules and larger intralobular ducts. Expressed in the retina. Present in urine within small membrane particles (at protein level). In the embryo, expressed on the apical side of neuroepithelial cells and of other epithelia such as lung buds, gut and ureter buds. In the adult, expressed at the apical side of the kidney tubules and of the ependymal layer of the brain. Not expressed in gut, liver, lung, pituitary, adrenal, heart or spleen. Localized to the nascent disk membranes at the base of the rod outer segment in the retina (at protein level). {ECO:0000269|PubMed:12514187, ECO:0000269|PubMed:17874118, ECO:0000269|PubMed:18654668, ECO:0000269|PubMed:19228982}.
Top Pathways	Transcriptional misregulation in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones

Prom1 antibody - N-terminal region (ARP61144_P050) - ARP61144_P050 from Aviva Systems Biology Prices $289.00 Sizes 100 µl Host Rabbit Clonality Polyclonal

CD133 antibody - 10R-8653 from Fitzgerald Prices $275.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone 13A4

Anti -CD133 (AC133, Antigen AC133, CD133, CD133 Antigen, CD133 Retinal Degeneration,CORD12, MCDR2, MSTP061, Prominin 1, Prominin-1, PROM1, PROM, Prominin-like Protein 1,PROML1, RP41, STGD4) - C2514-90F from USBiological Life Science Host Rat

Anti -CD133 (APC) (AC133, Antigen AC133, CD133, CD133 Antigen, CD133 Retinal Degeneration,CORD12, MCDR2, MSTP061, Prominin 1, Prominin-1, PROM1, PROM, Prominin-like Protein 1,PROML1, RP41, STGD4) - C2514-90J from USBiological Life Science Host Rat

Anti -CD133 (Biotin) (AC133, Antigen AC133, CD133, CD133 Antigen, CD133 RetinalDegeneration, CORD12, MCDR2, MSTP061, Prominin 1, Prominin-1, PROM1, PROM, Prominin-likeProtein 1, PROML1, RP41, STGD4) - C2514-90H from USBiological Life Science Host Rat

Anti -CD133 (PE) (AC133, Antigen AC133, CD133, CD133 Antigen, CD133 Retinal Degeneration,CORD12, MCDR2, MSTP061, Prominin 1, Prominin-1, PROM1, PROM, Prominin-like Protein 1,PROML1, RP41, STGD4) - C2514-90G from USBiological Life Science Host Rat

Prominin 1 Antibody - abx100859 from Abbexa Host Rabbit Clonality Polyclonal

Prominin 1 Antibody - abx114720 from Abbexa Host Rabbit Clonality Polyclonal

APC anti-mouse CD133 Antibody - 141207 from Biolegend Prices $120.00, $305.00 Sizes 25 µg, 100 µg Host Rat Clone 315-2C11

Biotin anti-mouse CD133 Antibody - 141205 from Biolegend Prices $105.00, $270.00 Sizes 25 µg, 100 µg Host Rat Clone 315-2C11

PE anti-mouse CD133 Antibody - 141203 from Biolegend Prices $115.00, $295.00 Sizes 25 µg, 100 µg Host Rat Clone 315-2C11

PE/Cy7 anti-mouse CD133 Antibody - 141209 from Biolegend Prices $145.00, $325.00 Sizes 25 µg, 100 µg Host Rat Clone 315-2C11

Purified anti-mouse CD133 Antibody - 141201 from Biolegend Prices $85.00, $250.00 Sizes 25 µg, 100 µg Host Rat Clone 315-2C11

Anti-PROM1 Antibody - 10-P2063 from ARP American Research Products Prices $269.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PROM1 - 10-P2063-1 from ARP American Research Products Host Rabbit Clonality Polyclonal

Anti-Prominin 1 (PROM1) - 20-3900 from ARP American Research Products Prices $319.00 Sizes 50 µg Host Rabbit Clonality Polyclonal

CD133 Polyclonal Antibody - PA006581-PA2063 from Syd Labs Prices $216.00 Sizes 100 µg

Prom1 Antibody - GWB-MW175D from Genway Biotech Prices $368.00 Sizes 50 µg Host Rabbit

Anti-PROM1 monoclonal antibody, clone 24B5 - DMABT-H22262 from Creative Diagnostics Host Rat Clonality Monoclonal Clone 24B5

PROM1, Polyclonal Antibody - MBS176243 from MyBioSource Prices $245.00 Sizes 100 µg Host Rabbit Clonality Polyclonal

Anti-PROM1 Antibody PA2063 - PA2063 from Boster Bio Prices $200.00 Sizes 1 Host Rabbit Clonality Polyclonal

Anti-Mouse CD133 (Prominin-1) Alexa Fluor® 488 - 53-1331 from eBioscience Prices $199.00 Sizes 25 µg Host Rat Clonality Monoclonal Clone 13A4

Anti-Mouse CD133 (Prominin-1) APC - 17-1331 from eBioscience Prices $279.00 Sizes 50 µg Host Rat Clonality Monoclonal Clone 13A4

Anti-Mouse CD133 (Prominin-1) Biotin - 13-1331 from eBioscience Prices $109.00, $279.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 13A4

Anti-Mouse CD133 (Prominin-1) FITC - 11-1331 from eBioscience Prices $109.00, $279.00 Sizes 25 µg, 100 µg Host Rat Clonality Monoclonal Clone 13A4

Search more