Prom1

Gene Symbol Prom1
Entrez Gene 19126
Alt Symbol 4932416E19Rik, AC133, CD133, Prom, Prom-1, Proml1
Species Mouse
Gene Type protein-coding
Description prominin 1
Other Description antigen AC133 homolog|prominin-1|prominin-like 1|prominin-like protein 1
Swissprots Q80XB6 Q80XB2 O54990 Q80XB3 O35408 Q8BH12
Accessions EDL37600 EDL37601 EDL37602 EDL37603 EDL37604 EDL37605 EDL37606 O54990 AF026269 AAB86715 AF039663 AAB96916 AF305215 AAO11840 AK029921 BAC26678 AK030027 BAC26745 AK085654 BAC39496 AY099088 AAM28245 AY223521 AAO72429 AY223522 AAO72430 BC028286 AAH28286 CJ054003 CX224587 EH108160 XM_006503786 XP_006503849 XM_006503788 XP_006503851 XM_006503789 XP_006503852 XM_006503790 XP_006503853 XM_006503791 XP_006503854 XM_011240703 XP_011239005 XM_011240704 XP_011239006 XM_011240705 XP_011239007 XM_011240706 XP_011239008 XM_011240707 XP_011239009 NM_001163577 NP_001157049 NM_001163578 NP_001157050 NM_001163581 NP_001157053 NM_001163582 NP_001157054 NM_001163583 NP_001157055 NM_001163584 NP_001157056 NM_001163585 NP_001157057 NM_008935 NP_032961
Function May play a role in cell differentiation, proliferation and apoptosis. Binds cholesterol in cholesterol-containing plasma membrane microdomains and may play a role in the organization of the apical plasma membrane in epithelial cells. During early retinal development acts as a key regulator of disk morphogenesis (PubMed:19228982). Involved in regulation of MAPK and Akt signaling pathways. In neuroblastoma cells suppresses cell differentiation such as neurite outgrowth in a RET-dependent manner. {ECO:0000269|PubMed:19228982}.
Subcellular Location Apical cell membrane; Multi-pass membrane protein. Cell projection, microvillus membrane; Multi-pass membrane protein. Cell projection, cilium, photoreceptor outer segment. Endoplasmic reticulum {ECO:0000250}. Endoplasmic reticulum-Golgi intermediate compartment {ECO:0000250}. Note=Found in extracellular membrane particles in various body fluids such as ventricular fluid of the developing brain and urine.
Tissue Specificity In the submandibular gland, expressed on the apical side of epithelial cells. In the parotid gland, expressed in the intercalated ducts. In the sublingual gland, expressed in intercalated ducts. In the extraorbital lacrimal gland, expressed in the intercalated tubules and larger intralobular ducts. Expressed in the retina. Present in urine within small membrane particles (at protein level). In the embryo, expressed on the apical side of neuroepithelial cells and of other epithelia such as lung buds, gut and ureter buds. In the adult, expressed at the apical side of the kidney tubules and of the ependymal layer of the brain. Not expressed in gut, liver, lung, pituitary, adrenal, heart or spleen. Localized to the nascent disk membranes at the base of the rod outer segment in the retina (at protein level). {ECO:0000269|PubMed:12514187, ECO:0000269|PubMed:17874118, ECO:0000269|PubMed:18654668, ECO:0000269|PubMed:19228982}.
Top Pathways Transcriptional misregulation in cancer

Mouse Prominin 1 Protein - abx068692 from Abbexa

Category Protein
Source E.coli
Species Mouse

Prominin 1 (PROM1), Mouse - 20-7800 from ARP American Research Products

Category Protein
Prices $469.00
Sizes 50 µg
Source E.coli
Species Mouse

Recombinant Prominin 1 (PROM1) - RPB516Mu01 from Cloud-clone

Category Protein
Source E.coli
Species Mouse

Prominin 1 (PROM1) - RPU143437 from Biomatik

Category Protein
Prices $220.00, $440.00, $660.00
Sizes 10 µg, 50 µg, 100 µg
Source E.coli
Species Mouse

Prominin 1 (PROM1), Recombinant Protein - MBS2009551 from MyBioSource

Category Protein
Prices $175.00, $360.00, $560.00
Sizes 10 µg, 50 µg, 100 µg
Source Prokaryotic expression
Species Mouse

Prominin-1 (Prom1), Recombinant Protein - MBS1143448 from MyBioSource

Category Protein
Prices $180.00, $490.00, $715.00, $950.00, $1,170.00, $1,170.00, $1,170.00, $1,400.00, $1,860.00, $1,860.00, $1,860.00, $2,760.00
Sizes 50 µg (E-Coli), 200 µg (E-Coli), 500 µg (E-Coli), 50 µg (Baculovirus), 1 mg (E-Coli), 50 µg (Mammalian-Cell), 500 µg (Yeast), 100 µg (Baculovirus), 100 µg (Mammalian-Cell), 1 mg (Yeast), 500 µg (Baculovirus), 1 mg (Baculovirus)
Source E Coli or Yeast or Baculovirus or Mammalian Cell
Species Mouse

Recombinant Mouse Prominin-1 (Prom1),Partial - CSB-EP018751MO from Cusabio

Category Protein
Source E.coli
Species Mouse

Recombinant Prominin 1 (PROM1) - RPU43437 from Biomatik

Category Protein
Prices $176.00, $360.00, $550.00, $656.00
Sizes 10 µg, 50 µg, 100 µg, 200 µg
Source E.coli
Species Mouse

PROM1 Recombinant Protein (OPCD06423) - OPCD06423 from Aviva Systems Biology

Category Protein
Source E.coli
Species Mouse

Recombinant Mouse Prominin-1(Prom1) ,partial,Yeast - CSB-YP018751MO from Cusabio

Category Protein
Source Yeast
Species Mouse

PROM1 Recombinant Protein (Mouse) (OPCA05265) - OPCA05265 from Aviva Systems Biology

Category Protein
Species Mouse
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