RHOH

Gene Symbol RHOH
Entrez Gene 399
Alt Symbol ARHH, TTF
Species Human
Gene Type protein-coding
Description ras homolog family member H
Other Description GTP-binding protein TTF|TTF, translocation three four|ras homolog gene family, member H|rho-related GTP-binding protein RhoH
Swissprots Q15669
Accessions CAH05283 CAH05284 EAW92960 EAW92961 EAW92962 Q15669 AA767445 AF498975 AAM21122 AI865435 AK097117 AK313744 BAG36484 AW402442 AY673952 AY673953 AY673954 AY673955 AY673956 BC014261 AAH14261 BG025818 BI818548 BI908453 BM457874 BU934664 BX413967 CA447396 CD703012 CR450349 CAG29345 DA383563 DA815617 DA906265 DA950405 DA951252 DB115332 DB119883 DQ892629 ABM83555 DQ895867 ABM86793 Z35227 CAA84538 XM_011513692 XP_011511994 NM_001278359 NP_001265288 NM_001278360 NP_001265289 NM_001278361 NP_001265290 NM_001278362 NP_001265291 NM_001278363 NP_001265292 NM_001278364 NP_001265293 NM_001278365 NP_001265294 NM_001278366 NP_001265295 NM_001278367 NP_001265296 NM_001278368 NP_001265297 NM_001278369 NP_001265298 NM_004310 NP_004301
Function Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation
Subcellular Location Cytoplasm {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}. Cell membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.
Tissue Specificity Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis. {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}.
Top Pathways Leukocyte transendothelial migration

Rho H (N-20) - sc-20603 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal

Rho H (H-63) - sc-366409 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
Rho H (H-63): sc-366409. Western blot analysis of Rho H expression in mouse small intestine tissue extract.

Anti-RHOH antibody - ab118507 from Abcam

Prices $407.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
ab118507 at 5 µg/ml staining RHOH in Formalin-Fixed, Paraffin-Embedded Human colon tissue.

Anti-RHOH antibody - ab138123 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Anti-RHOH antibody (ab138123) at 1/500 dilution + RAW 264.7 cell lysates at 30 µg

Anti-RHOH antibody - C-terminal - ab139155 from Abcam

Prices $370.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
Anti-RHOH antibody - C-terminal (ab139155) at 1/100 dilution + ZR-75-1 cell line lysates at 35 µgdeveloped using the ECL technique

Anti-TTF / RHOH Antibody (clone 4H5) - LS-C196694 from LifeSpan Bioscience

Prices $355.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H5

Anti-TTF / RHOH Antibody (aa155-184, AP) - LS-C239982 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (aa155-184, Biotin) - LS-C239983 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (aa155-184, APC) - LS-C239984 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (aa155-184, FITC) - LS-C239985 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (aa155-184, Azide-free, HRP) - LS-C247998 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (aa155-184, PE) - LS-C239986 from LifeSpan Bioscience

Prices $545.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (aa155-184) - LS-C324667 from LifeSpan Bioscience

Prices $345.00
Sizes 200 µl
Host Rabbit
Clonality Polyclonal

Anti-TTF / RHOH Antibody (Met134) - LS-C177126 from LifeSpan Bioscience

Prices $345.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of Rho H (M134) pAb in extracts from HT-29 cells.

Anti-TTF / RHOH Antibody (aa155-184) - LS-C158847 from LifeSpan Bioscience

Prices $295.00
Sizes 400 µl
Host Rabbit
Clonality Polyclonal
RHOH Antibody western blot of ZR-75-1 cell line lysates (35 ug/lane). The RHOH antibody detected the RHOH protein (arrow).

Anti-TTF / RHOH Antibody (aa85-134) - LS-C200602 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
Western blot of the lysates from RAW264.7cells using RhoH antibody.

Anti-TTF / RHOH Antibody - LS-C334657 from LifeSpan Bioscience

Prices $255.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Western blot analysis of extracts of various cell lines, using RHOH antibody.

Anti-TTF / RHOH Antibody (aa141-190) IHC-plus™ - LS-B5771 from LifeSpan Bioscience

Prices $395.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
Anti-RHOH antibody IHC of human colon. Immunohistochemistry of formalin-fixed, paraffin-embedded tissue after heat-induced antigen retrieval. Antibody LS-B5771 concentration 5 ug/ml.

RhoH Antibody - NBP1-88816 from Novus Biologicals

Prices $419.00
Sizes 100 µl
Host Rabbit
Clonality Polyclonal
Western Blot: RhoH Antibody [NBP1-88816] - Lane 1: Marker [kDa] 250, 130, 95, 72, 55, 36, 28, 17, 10. Lane 2: Negative control (vector only transfected HEK293T lysate). Lane 3: Over-expression lysate (Co-expressed with a C-terminal myc-DDK tag (3.1 kDa) in mammalian HEK293T cells).

RhoH Antibody (3D3) - H00000399-M03 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D3
Sandwich ELISA: RhoH Antibody (3D3) [H00000399-M03] - Detection limit for recombinant GST tagged RHOH is approximately 1ng/ml as a capture antibody.

RhoH Antibody - H00000399-A01 from Novus Biologicals

Host Mouse
Clonality Polyclonal

RhoH Antibody (2G7) - H00000399-M04 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 2G7

RhoH Antibody (4H5) - H00000399-M01 from Novus Biologicals

Prices $359.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 4H5

Monoclonal Anti-RHOH antibody produced in mouse - WH0000399M3 from Sigma-Aldrich

Prices $347.00
Sizes 100 µg
Host Mouse
Clonality Monoclonal
Clone 3D3
<B>Sandwich ELISA</B><BR/>Monoclonal Anti-RHOH, <B>Cat. No. WH0000399M3</B>: the detection limit for recombinant GST tagged RHOH is approximately 1ng/mL.

Anti-RHOH, C-Terminal antibody produced in rabbit - SAB4501761 from Sigma-Aldrich

Prices $335.50
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
<B>Immunofluorescence</B><BR/>Anti-RHOH, C-Terminal: <B>Cat. No. SAB4501761</B>: Immunofluorescence of A549 cells using Anti-RHOH, C-Terminal antibody. Cells on the left were treated with the Anti-RHOH, C-Terminal antibody. Cells on the right (negative control) were treated with both Anti-RHOH, C-Terminal antibody and the synthesized immunogen peptide.
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