RHOH

Gene Symbol	RHOH
Entrez Gene	399
Alt Symbol	ARHH, TTF
Species	Human
Gene Type	protein-coding
Description	ras homolog family member H
Other Description	GTP-binding protein TTF|TTF, translocation three four|ras homolog gene family, member H|rho-related GTP-binding protein RhoH
Swissprots	Q15669
Accessions	CAH05283 CAH05284 EAW92960 EAW92961 EAW92962 Q15669 AA767445 AF498975 AAM21122 AI865435 AK097117 AK313744 BAG36484 AW402442 AY673952 AY673953 AY673954 AY673955 AY673956 BC014261 AAH14261 BG025818 BI818548 BI908453 BM457874 BU934664 BX413967 CA447396 CD703012 CR450349 CAG29345 DA383563 DA815617 DA906265 DA950405 DA951252 DB115332 DB119883 DQ892629 ABM83555 DQ895867 ABM86793 Z35227 CAA84538 XM_011513692 XP_011511994 NM_001278359 NP_001265288 NM_001278360 NP_001265289 NM_001278361 NP_001265290 NM_001278362 NP_001265291 NM_001278363 NP_001265292 NM_001278364 NP_001265293 NM_001278365 NP_001265294 NM_001278366 NP_001265295 NM_001278367 NP_001265296 NM_001278368 NP_001265297 NM_001278369 NP_001265298 NM_004310 NP_004301
Function	Negative regulator of hematopoietic progenitor cell proliferation, survival and migration. Critical regulator of thymocyte development and T-cell antigen receptor (TCR) signaling by mediating recruitment and activation of ZAP70. Required for phosphorylation of CD3Z, membrane translocation of ZAP70 and subsequent activation of the ZAP70-mediated pathways. Essential for efficient beta-selection and positive selection by promoting the ZAP70-dependent phosphorylation of the LAT signalosome during pre-TCR and TCR signaling. Crucial for thymocyte maturation during DN3 to DN4 transition and during positive selection. Plays critical roles in mast cell function by facilitating phosphorylation of SYK in Fc epsilon RI-mediated signal transduction. Essential for the phosphorylation of LAT, LCP2, PLCG1 and PLCG2 and for Ca(2+) mobilization in mast cells (By similarity). Binds GTP but lacks intrinsic GTPase activity and is resistant to Rho-specific GTPase-activating proteins. Inhibits the activation
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}. Cell membrane {ECO:0000250}; Lipid- anchor {ECO:0000250}; Cytoplasmic side {ECO:0000250}. Note=Colocalizes together with ZAP70 in the immunological synapse. {ECO:0000250}.
Tissue Specificity	Expressed only in hematopoietic cells. Present at very high levels in the thymus, less abundant in the spleen, and least abundant in the bone marrow. Expressed at a higher level in the TH1 subtype of T-helper cells than in the TH2 subpopulation. Expressed in neutrophils under inflammatory conditions, such as cystic fibrosis, ulcerative colitis and appendicitis. {ECO:0000269|PubMed:11809807, ECO:0000269|PubMed:19414807}.
Top Pathways	Leukocyte transendothelial migration

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Rho H CRISPR/Cas9 KO Plasmid (h) - sc-409165 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H HDR Plasmid (h) - sc-409165-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H Double Nickase Plasmid (h) - sc-409165-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H Double Nickase Plasmid (h2) - sc-409165-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H CRISPR Activation Plasmid (h) - sc-409165-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H CRISPR Activation Plasmid (h2) - sc-409165-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H Lentiviral Activation Particles (h) - sc-409165-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H Lentiviral Activation Particles (h2) - sc-409165-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Rho H siRNA (h) - sc-106503 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rho H shRNA Plasmid (h) - sc-106503-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Rho H shRNA (h) Lentiviral Particles - sc-106503-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

RhoH RNAi - H00000399-R01 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU003891 from Sigma-Aldrich Category siRNA Prices $250.00 Sizes 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN18258 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND18258 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

MISSION® 3′UTR Lenti GoClone™ - HUTR06121 from Sigma-Aldrich Category miRNA Prices $350.00 Sizes hutr06121

RHOH siRNA (Human) - CRH0288 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

RHOH - MBS8202286 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human RHOH (NM_004310.3) - SHH395368 from Creative biogene Category siRNA Species Reactivities Human

shRNA set against Human RHOH(NM_004310.3) - SHR181164 from Creative biogene Category siRNA Species Reactivities Human

RHOH shRNA Plasmid (Human) - CHH0288 from Cohesion Biosciences Category siRNA Prices $500.00, $750.00 Sizes 150 µg, 300 µg Species Reactivities Human

RHOH miRNA 3'UTR clone - MiUTR1H-08815 from Creative biogene Species Reactivities Human

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