APAF1

Gene Symbol	APAF1
Entrez Gene	317
Alt Symbol	APAF-1, CED4
Species	Human
Gene Type	protein-coding
Description	apoptotic peptidase activating factor 1
Other Description	apoptotic protease-activating factor 1
Swissprots	O43297 Q9UNC9 Q9UGN8 Q9UGN9 B2RMX8 Q9BXZ6 Q9UJ62 Q9UBZ5 Q7Z438 Q9UJ60 Q9UGP0 Q9UJ67 Q9UJ59 Q9UJ64 Q9UJ65 O14727 Q9UJ61 Q9UJ58 Q9UJ66 Q9UJ63
Accessions	CAB65085 CAB65086 CAB65087 EAW97603 EAW97604 EAW97605 EAW97606 EAW97607 EAW97608 EAW97609 EAW97610 EAW97611 O14727 AB007873 BAA24843 AB103079 BAC77343 AF013263 AAC51678 AF134397 AAD38344 AF149794 AAD34016 AF248734 AAK28401 AJ243003 CAB55579 AJ243004 CAB55580 AJ243005 CAB55581 AJ243006 CAB55582 AJ243007 CAB55583 AJ243008 CAB55584 AJ243009 CAB55585 AJ243010 CAB55586 AJ243011 CAB55587 AJ243048 CAB55588 AJ243107 CAB56462 AK307509 BC136531 AAI36532 BC136532 AAI36533 BC150255 AAI50256 EF560718 ABQ59028 XM_011538252 XP_011536554 XM_011538253 XP_011536555 XM_011538254 XP_011536556 XM_011538255 XP_011536557 XR_429095 NM_001160 NP_001151 NM_013229 NP_037361 NM_181861 NP_863651 NM_181868 NP_863658 NM_181869 NP_863659
Function	Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12804598}.
Tissue Specificity	Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Top Pathways	Apoptosis, Huntington's disease, Amyotrophic lateral sclerosis (ALS), Tuberculosis, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human APAF1 / APAF-1 ELISA Kit (Sandwich ELISA) - LS-F4412 from LifeSpan Bioscience Category ELISA Kit Prices $690.00 Sizes 1 plate Sensitivity 0.057 ng/ml Range 0.156-10 ng/ml

Human APAF1 / APAF-1 ELISA Kit (Cell-Based ELISA) - LS-F1800 from LifeSpan Bioscience Category ELISA Kit Prices $450.00 Sizes 1 plate Range 0.156-10 ng/ml

Rat APAF1 / APAF-1 ELISA Kit (Sandwich ELISA) - LS-F8140 from LifeSpan Bioscience Category ELISA Kit Prices $740.00 Sizes 1 plate Sensitivity 0.156 ng/ml Range 0.156-10 ng/ml

Rat APAF1 / APAF-1 ELISA Kit (Sandwich ELISA) - LS-F10848 from LifeSpan Bioscience Category ELISA Kit Prices $600.00 Sizes 1 plate Sensitivity 0.312 Range 0.156-10 ng/ml

Human Apaf-1 ELISA Kit - abx054561 from Abbexa Category ELISA Kit Sensitivity 6.5 pg/ml Range 36 pg/ml - 2000 pg/ml

Human APAF1 ELISA Kit - abx054911 from Abbexa Category ELISA Kit

Human APAF1 ELISA Kit - abx150694 from Abbexa Category ELISA Kit Sensitivity 0.064 ng/ml Range 0.156 ng/ml - 10 ng/ml

Apoptosis Protease Activating Factor 1, APAF1, Human, ELISA Kit - E-EL-H0481 from ARP American Research Products Category ELISA Kit Prices $522.00 Sizes 96 t Sensitivity 0.094 Range 0.156-10ng/mL

Apoptosis protease activating factor-1, Apaf-1, Human, ELISA Kit - CSB-E08996h from ARP American Research Products Category ELISA Kit Prices $550.00, $790.00, $791.00, $794.00 Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

Apoptotic Peptidase Activating Factor 1 (APAF1), Human, ELISA Kit - SEB054Hu from ARP American Research Products Category ELISA Kit Prices $685.00 Sizes 96 t Sensitivity 0.064ng/mL Range 0.156-10ng/mL

Apoptotic Peptidase Activating Factor 1, Human, ELISA Kit - E01A0629 from ARP American Research Products Category ELISA Kit Prices $535.00, $735.00 Sizes 48 t, 96 t Sensitivity 0.1ng/ml Range 0.5-10ng/mL,

Apoptotic protease-activating factor 1, APAF1, Human, ELISA Kit - E1054h from ARP American Research Products Category ELISA Kit Prices $596.00 Sizes 96 t

Apoptotic Peptidase Activating Factor 1, APAF1, Mouse, ELISA Kit - E-EL-M0143 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t Sensitivity 4.688 Range 7.813-500pg/mL

Apoptosis Protease Activating Factor-1, APAF-1, Rabbit, ELISA Kit - E-EL-RB0851 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Apoptosis Protease Activating Factor-1, APAF-1, Chicken, ELISA Kit - E-EL-Ch0713 from ARP American Research Products Category ELISA Kit Prices $504.00 Sizes 96 t

Apoptosis Protease Activating Factor-1, APAF-1, Porcine, ELISA Kit - E-EL-P1555 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Apoptosis Protease Activating Factor-1, APAF-1, Monkey, ELISA Kit - E-EL-MK0476 from ARP American Research Products Category ELISA Kit Prices $585.00 Sizes 96 t

Apoptotic Peptidase Activating Factor 1 (APAF1), Human, CLIA Kit - SCB054Hu from ARP American Research Products Category CLIA Kit Prices $840.00 Sizes 96 t Sensitivity 0.061ng/mL Range 0.156-10ng/mL

Human APAF1 ELISA Kit - HA0636 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

Anserine APAF1 ELISA Kit - AA0636 from NeoScientific Category ELISA Kit Prices $495.00 Sizes 96 t

APAF-1-ALT Colorimetric Cell-Based ELISA Kit - CB5044 from Assay Biotechnology Category ELISA Kit Prices $380.00, $760.00, $1,140.00 Sizes 1 kit, 2 kits, 3 kits Range > 5000 Cells

Human Apoptotic Peptidase Activating Factor 1 (APAF1) CLIA Kit - DEEL0353 from Creative Diagnostics Category CLIA Kit Sensitivity 0.061 ng/mL Range 0.156-10 ng/mL

Human APAF1(Apoptosis Protease Activating Factor 1) ELISA Kit - E-EL-H0481 from Elabscience Category ELISA Kit Sensitivity 0.10 ng/mL Range 0.16—10 ng/mL

Human APAF1 (Apoptosis Protease Activating Factor 1) CLIA Kit - E-CL-H0393 from Elabscience Category CLIA Kit Sensitivity 18.75 pg/mL Range Average Recovery (%)

APAF-1, ELISA Kit - MBS2503187 from MyBioSource Category ELISA Kit Prices $450.00, $535.00, $2,255.00, $3,975.00 Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells Sensitivity 37.5pg/mL Range 62.5-4000pg/mL

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