APAF1

Gene Symbol	APAF1
Entrez Gene	317
Alt Symbol	APAF-1, CED4
Species	Human
Gene Type	protein-coding
Description	apoptotic peptidase activating factor 1
Other Description	apoptotic protease-activating factor 1
Swissprots	O43297 Q9UNC9 Q9UGN8 Q9UGN9 B2RMX8 Q9BXZ6 Q9UJ62 Q9UBZ5 Q7Z438 Q9UJ60 Q9UGP0 Q9UJ67 Q9UJ59 Q9UJ64 Q9UJ65 O14727 Q9UJ61 Q9UJ58 Q9UJ66 Q9UJ63
Accessions	CAB65085 CAB65086 CAB65087 EAW97603 EAW97604 EAW97605 EAW97606 EAW97607 EAW97608 EAW97609 EAW97610 EAW97611 O14727 AB007873 BAA24843 AB103079 BAC77343 AF013263 AAC51678 AF134397 AAD38344 AF149794 AAD34016 AF248734 AAK28401 AJ243003 CAB55579 AJ243004 CAB55580 AJ243005 CAB55581 AJ243006 CAB55582 AJ243007 CAB55583 AJ243008 CAB55584 AJ243009 CAB55585 AJ243010 CAB55586 AJ243011 CAB55587 AJ243048 CAB55588 AJ243107 CAB56462 AK307509 BC136531 AAI36532 BC136532 AAI36533 BC150255 AAI50256 EF560718 ABQ59028 XM_011538252 XP_011536554 XM_011538253 XP_011536555 XM_011538254 XP_011536556 XM_011538255 XP_011536557 XR_429095 NM_001160 NP_001151 NM_013229 NP_037361 NM_181861 NP_863651 NM_181868 NP_863658 NM_181869 NP_863659
Function	Oligomeric Apaf-1 mediates the cytochrome c-dependent autocatalytic activation of pro-caspase-9 (Apaf-3), leading to the activation of caspase-3 and apoptosis. This activation requires ATP. Isoform 6 is less effective in inducing apoptosis. {ECO:0000269|PubMed:10393175, ECO:0000269|PubMed:12804598}.
Subcellular Location	Cytoplasm {ECO:0000269|PubMed:12804598}.
Tissue Specificity	Ubiquitous. Highest levels of expression in adult spleen and peripheral blood leukocytes, and in fetal brain, kidney and lung. Isoform 1 is expressed in heart, kidney and liver.
Top Pathways	Apoptosis, Huntington's disease, Amyotrophic lateral sclerosis (ALS), Tuberculosis, Alzheimer's disease

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

SignalSilence ® Apaf-1 siRNA I - 6229 from Cell Signaling Technology Category siRNA Prices $249.00 Sizes 300 µl (3 nmol)

Apaf-1 CRISPR/Cas9 KO Plasmid (h) - sc-401291 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 HDR Plasmid (h) - sc-401291-HDR from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 Double Nickase Plasmid (h) - sc-401291-NIC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 Double Nickase Plasmid (h2) - sc-401291-NIC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 CRISPR Activation Plasmid (h) - sc-401291-ACT from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 CRISPR Activation Plasmid (h2) - sc-401291-ACT-2 from Santa Cruz Biotechnology Category CRISPR Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 Lentiviral Activation Particles (h) - sc-401291-LAC from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 Lentiviral Activation Particles (h2) - sc-401291-LAC-2 from Santa Cruz Biotechnology Prices $345.00 Sizes 20 µg Species Reactivities Human

Apaf-1 siRNA (h) - sc-29201 from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Apaf-1 shRNA Plasmid (h) - sc-29201-SH from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

Apaf-1 shRNA (h) Lentiviral Particles - sc-29201-V from Santa Cruz Biotechnology Category siRNA Prices $258.00 Sizes 10 µm Species Reactivities Human

APAF-1 RNAi - H00000317-R05 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

APAF-1 RNAi - H00000317-R04 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

APAF-1 RNAi - H00000317-R03 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

APAF-1 RNAi - H00000317-R02 from Novus Biologicals Category siRNA Prices $399.00 Sizes 20 nmol Species Reactivities Human

MISSION® esiRNA - EHU103411 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

MISSION® esiRNA - EHU087111 from Sigma-Aldrich Category siRNA Prices $140.00, $250.00 Sizes 20 µg, 50 µg

CompoZr® Knockout ZFN Kit - CKOZFN3303 from Sigma-Aldrich Category ZFN Kit Prices $4,999.00 Sizes 1 kt

CompoZr® Knockout ZFN Kit, ZFN plasmid only - CKOZFND3303 from Sigma-Aldrich Category ZFN Kit Prices $3,999.00 Sizes 1 kt

APAF1 siRNA (Human) - CRH0218 from Cohesion Biosciences Category siRNA Prices $340.00, $510.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

APAF-1 RNAi - H00000317-R01 from Novus Biologicals Category siRNA Prices $409.00 Sizes 20 nmol Species Reactivities Human

APAF-1 - MBS826818 from MyBioSource Prices $255.00 Sizes 5 od Species Reactivities Human

APAF1 - MBS8221536 from MyBioSource Prices $365.00, $515.00 Sizes 15 nmol, 30 nmol Species Reactivities Human

shRNA set against Human Apaf1 (NM_001160.2) - SHH238006 from Creative biogene Category siRNA Species Reactivities Human

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