SFN

Gene Symbol SFN
Entrez Gene 2810
Alt Symbol YWHAS
Species Human
Gene Type protein-coding
Description stratifin
Other Description 14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1
Swissprots Q6FH51 Q96DH0 P31947 Q6FH30
Accessions AAC52029 EAX07786 EAX07787 P31947 AF029082 AAC52030 BC000329 AAH00329 BC000995 AAH00995 BC001550 AAH01550 BC002995 AAH02995 BC023552 AAH23552 CR541905 CAG46703 CR541926 CAG46724 DQ894162 ABM85088 M93010 AAA59546 NM_006142 NP_006133
Function Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.
Subcellular Location Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue Specificity Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Top Pathways Cell cycle, p53 signaling pathway, Aldosterone-regulated sodium reabsorption

SFN-Over-expression-Lysate - LY12617a from Abgent, a WuXi AppTec company

Category Cell Lysate
Prices $325.00
Sizes 100 µg
Western blot analysis of his-tag SFN (arrow) using his tag antibody. 293T cell lysates (2 ug/lane) either nontransfected (Lane 1) or transiently transfected with the SFN gene

SFN overexpression lysate - LY401850 from Acris Antibodies

Category Cell Lysate
Prices $280.00
Sizes 100 µg

SFN 293 Cell Lysate - 401649 from ABBIOTEC

Category Cell Lysate
Prices $392.00
Sizes 100 µg

14-3-3 sigma/Stratifin Overexpression Lysate (Native) - NBL1-15882 from Novus Biologicals

Category Cell Lysate
Prices $329.00
Sizes 100 µg
Western Blot: 14-3-3 sigma/Stratifin Overexpression Lysate (Adult Normal) [NBL1-15882] Left-Empty vector transfected control cell lysate (HEK293 cell lysate); Right -Over-expression Lysate for 14-3-3 sigma/Stratifin.

14-3-3 σ (h): 293T Lysate - sc-175742 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

14-3-3 σ (h3): 293T Lysate - sc-110782 from Santa Cruz Biotechnology

Category Cell Lysate
Prices $205.00
Sizes 100 µg/200 µl
Species Human

SFN Over-expression Lysate Product - GWB-55C5F7 from Genway Biotech

Category Cell Lysate
Prices $346.00
Sizes 100 µg
Species Human

14-3-3 sigma/Stratifin Overexpression Lysate (Denatured) - H00002810-T01 from Novus Biologicals

Category Cell Lysate
Prices $279.00
Sizes 100 µl

Panoply™ Human SFN Knockdown Stable Cell Line - CSC-DC014107 from Creative biogene

Category Cell Line
Species Human

Human SFN Knockout Cell Line-HeLa - CSC-RT0973 from Creative biogene

Category Cell Line
Species Human

SFN KO Cell Lysate-HeLa - CLKO-0464 from Creative biogene

Category Cell Lysate
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