SFN

Gene Symbol	SFN
Entrez Gene	2810
Alt Symbol	YWHAS
Species	Human
Gene Type	protein-coding
Description	stratifin
Other Description	14-3-3 protein sigma|14-3-3 sigma|epithelial cell marker protein 1
Swissprots	Q6FH51 Q96DH0 P31947 Q6FH30
Accessions	AAC52029 EAX07786 EAX07787 P31947 AF029082 AAC52030 BC000329 AAH00329 BC000995 AAH00995 BC001550 AAH01550 BC002995 AAH02995 BC023552 AAH23552 CR541905 CAG46703 CR541926 CAG46724 DQ894162 ABM85088 M93010 AAA59546 NM_006142 NP_006133
Function	Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53. {ECO:0000269|PubMed:18382127}.
Subcellular Location	Cytoplasm. Nucleus {ECO:0000250}. Secreted. Note=May be secreted by a non-classical secretory pathway.
Tissue Specificity	Present mainly in tissues enriched in stratified squamous keratinizing epithelium.
Top Pathways	Cell cycle, p53 signaling pathway, Aldosterone-regulated sodium reabsorption

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Human 14-3-3 sigma full length protein - ab88174 from Abcam Category Protein Prices $235.00 Sizes 100 µl Source Saccharomyces cerevisiae Species Human

Human 14-3-3 sigma full length protein - ab85271 from Abcam Category Protein Prices $188.00 Sizes 20 µg Source E. coli Species Human

Human 14-3-3 sigma full length protein - ab40599 from Abcam Category Protein Prices $192.00 Sizes 50 µg Source E. coli Species Human

Human 14-3-3 sigma peptide - ab105198 from Abcam Category Peptide Prices $176.00 Sizes 100 µg

SFN-Antibody-Center-Blocking-Peptide - BP18803c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

SFN-Antibody-C-term-Blocking-peptide - BP5993b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

14-3-3 sigma blocking peptide - GTX89431-PEP from GeneTex Category Peptide Prices $239.00 Sizes 100 μg Species Human, Mouse, Dog, Pig, Rat

Stratifin Protein (OPPA02227) - OPPA02227 from Aviva Systems Biology Category Protein Prices $100.00 Sizes 5 µg Source E. Coli

Human YWHAS GST tag protein - orb83490 from Biorbyt Category Protein Prices $238.00, $357.00 Sizes 20 μg, 100 μg Source E. coli Species Human

Human Stratifin protein - orb80885 from Biorbyt Category Protein Prices $170.00, $289.00 Sizes 5 μg, 25 μg Species Human

Human YWHAS protein - orb83503 from Biorbyt Category Protein Prices $510.00, $748.00 Sizes 100 μg, 200 μg Source E. coli Species Human

Human SFN protein - orb49669 from Biorbyt Category Protein Prices $323.00, $485.00, $1,904.00, $2,695.00 Sizes 10 μg, 50 μg, 500 μg, 1 mg Species Human

Human SFN Protein - abx060030 from Abbexa Category Protein Source Yeast Species Human

Human Stratifin Protein - abx069174 from Abbexa Category Protein Source E.coli Species Human

Stratifin Peptide - AC21-0839-P from Abcore Category Peptide Prices $160.00 Sizes 100 µg

14-3-3 protein sigma / SFN (1-248) - AR09318PU-L from Acris Antibodies Category Protein Prices $695.00 Sizes 500 µg Source E. coli Species Human

14-3-3 protein sigma / SFN (1-248) - AR09318PU-N from Acris Antibodies Category Protein Prices $305.00 Sizes 100 µg Source E. coli Species Human

14-3-3 protein sigma / SFN - H00002810-P01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

14-3-3 protein sigma / SFN - H00002810-P01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

14-3-3 protein sigma / SFN - H00002810-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Species Human

14-3-3 protein sigma / SFN - H00002810-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Species Human

14-3-3 sigma, 1-248aa, Human, E.coli - 01-2057S from ARP American Research Products Category Protein Prices $159.00, $339.00, $749.00 Sizes 20 µg, 100 µg, 500 µg Species Human

Stratifin (SFN), Human - 20-9236 from ARP American Research Products Category Protein Prices $369.00 Sizes 50 µg Source E.coli Species Human

Stratifin, Human, Recombinant - 19-C173 from ARP American Research Products Category Protein Prices $119.00 Sizes 10 µg Source E. coli Species Human

14-3-3 sigma Peptide - 45-174P from ProSci Category Peptide Prices $175.00 Sizes 100 µg Species Human

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