CASP3

Gene Symbol CASP3
Entrez Gene 836
Alt Symbol CPP32, CPP32B, SCA-1
Species Human
Gene Type protein-coding
Description caspase 3, apoptosis-related cysteine peptidase
Other Description CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
Swissprots Q96AN1 Q96KP2 D3DP53 P42574 A8K5M2
Accessions AAO25654 CAG17895 CAV28500 CBX53863 CBX53864 EAX04673 EAX04674 EAX04675 EAX04676 P42574 AJ413269 CAC88866 AK291337 BAF84026 AU127028 AU133051 BC016926 AAH16926 BU753483 BX647609 CAI46084 DQ891543 ABM82469 DQ894731 ABM85657 U13737 AAA65015 U13738 AAB60355 U26943 AAA74929 XM_011532301 XP_011530603 NM_004346 NP_004337 NM_032991 NP_116786
Function Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.
Subcellular Location Cytoplasm.
Tissue Specificity Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Top Pathways TNF signaling pathway, Apoptosis, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer