CASP3

Gene Symbol	CASP3
Entrez Gene	836
Alt Symbol	CPP32, CPP32B, SCA-1
Species	Human
Gene Type	protein-coding
Description	caspase 3, apoptosis-related cysteine peptidase
Other Description	CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
Swissprots	Q96AN1 Q96KP2 D3DP53 P42574 A8K5M2
Accessions	AAO25654 CAG17895 CAV28500 CBX53863 CBX53864 EAX04673 EAX04674 EAX04675 EAX04676 P42574 AJ413269 CAC88866 AK291337 BAF84026 AU127028 AU133051 BC016926 AAH16926 BU753483 BX647609 CAI46084 DQ891543 ABM82469 DQ894731 ABM85657 U13737 AAA65015 U13738 AAB60355 U26943 AAA74929 XM_011532301 XP_011530603 NM_004346 NP_004337 NM_032991 NP_116786
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Top Pathways	TNF signaling pathway, Apoptosis, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

CASP3 overexpression lysate - LY403215 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP3 overexpression lysate - LY418048 from Acris Antibodies Category Cell Lysate Prices $280.00 Sizes 100 µg

CASP3 293 Cell Lysate - 408431 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

CASP3 293 Cell Lysate - 402791 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg

Caspase-3 Overexpression Lysate (Native) - NBL1-08710 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

Caspase-3 Overexpression Lysate (Native) - NBL1-08711 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

caspase-3 (h): 293T Lysate - sc-113427 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

caspase-3 (h2): 293T Lysate - sc-176260 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

caspase-3 (h3): 293T Lysate - sc-176342 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

caspase-3 (h4): 293 Lysate - sc-158344 from Santa Cruz Biotechnology Category Cell Lysate Prices $205.00 Sizes 100 µg/200 µl Species Human

CASP3 Over-expression Lysate Product - GWB-E9C344 from Genway Biotech Category Cell Lysate Prices $346.00 Sizes 100 µg Species Human

CASP3 Over-expression Lysate Product - GWB-A87D50 from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

Caspase-3 Overexpression Lysate (Denatured) - H00000836-T01 from Novus Biologicals Category Cell Lysate Prices $279.00 Sizes 100 µl

CASP3-knockout Cell lysate - LC810029 from Acris Antibodies Category Cell Lysate Prices $495.00 Sizes 100 µg

Panoply™ Human CASP3 Knockdown Stable Cell Line - CSC-DC002394 from Creative biogene Category Cell Line Species Human

Human CASP3 Knockout Cell Line-HeLa - CSC-RT0524 from Creative biogene Category Cell Line Species Human

CASP3 KO Cell Lysate-HeLa - CLKO-0029 from Creative biogene Category Cell Lysate

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