CASP3

Gene Symbol	CASP3
Entrez Gene	836
Alt Symbol	CPP32, CPP32B, SCA-1
Species	Human
Gene Type	protein-coding
Description	caspase 3, apoptosis-related cysteine peptidase
Other Description	CASP-3|CPP-32|PARP cleavage protease|SREBP cleavage activity 1|apopain|caspase 3, apoptosis-related cysteine protease|caspase-3|cysteine protease CPP32|procaspase3|protein Yama
Swissprots	Q96AN1 Q96KP2 D3DP53 P42574 A8K5M2
Accessions	AAO25654 CAG17895 CAV28500 CBX53863 CBX53864 EAX04673 EAX04674 EAX04675 EAX04676 P42574 AJ413269 CAC88866 AK291337 BAF84026 AU127028 AU133051 BC016926 AAH16926 BU753483 BX647609 CAI46084 DQ891543 ABM82469 DQ894731 ABM85657 U13737 AAA65015 U13738 AAB60355 U26943 AAA74929 XM_011532301 XP_011530603 NM_004346 NP_004337 NM_032991 NP_116786
Function	Involved in the activation cascade of caspases responsible for apoptosis execution. At the onset of apoptosis it proteolytically cleaves poly(ADP-ribose) polymerase (PARP) at a '216-Asp-|-Gly-217' bond. Cleaves and activates sterol regulatory element binding proteins (SREBPs) between the basic helix-loop- helix leucine zipper domain and the membrane attachment domain. Cleaves and activates caspase-6, -7 and -9. Involved in the cleavage of huntingtin. Triggers cell adhesion in sympathetic neurons through RET cleavage. {ECO:0000269|PubMed:21357690, ECO:0000269|PubMed:7596430}.
Subcellular Location	Cytoplasm.
Tissue Specificity	Highly expressed in lung, spleen, heart, liver and kidney. Moderate levels in brain and skeletal muscle, and low in testis. Also found in many cell lines, highest expression in cells of the immune system.
Top Pathways	TNF signaling pathway, Apoptosis, Viral carcinogenesis, Non-alcoholic fatty liver disease (NAFLD), MicroRNAs in cancer

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human active Caspase-3 full length protein - ab198447 from Abcam Category Protein Prices $1,250.00 Sizes 50 µg Source E. coli Species Human

Active human active Caspase-3 full length protein - ab52101 from Abcam Category Protein Prices $398.00 Sizes 100 units Source E. coli Species Human

Active human Caspase-3 full length protein - ab52314 from Abcam Category Protein Prices $340.00 Sizes 5 µg Source E. coli Species Human

Active mouse Caspase-3 full length protein - ab52071 from Abcam Category Protein Prices $471.00 Sizes 100 units Source E. coli Species Mouse

Active rat active Caspase 3 recombinant protein - ab52072 from Abcam Category Protein Prices $471.00 Sizes 100 units Source E. coli Species Rat

Human active + pro Caspase 3 peptide - ab13848 from Abcam Category Peptide Source CHO Species Human

Human Caspase-3 peptide - ab7990 from Abcam Category Peptide Species Human

Human Caspase-3 peptide - ab38283 from Abcam Category Peptide Prices $181.00 Sizes 50 µg Species Human

Human Caspase-3 peptide - ab22794 from Abcam Category Peptide Prices $181.00 Sizes 100 µg Species Human

Human Caspase-3 protein fragment - ab180336 from Abcam Category Protein Prices $357.00 Sizes 50 µg Source E. coli Species Human

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E920 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E10609 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E30114 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E7676 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E7505 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E7504 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E22306 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E7469 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E21584 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E26116 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

CASP3 / Caspase 3 Antibody Blocking Peptide - LS-E9058 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human Caspase-3 Protein - H00000836-P02 from Novus Biologicals Category Protein Prices $319.00 Sizes 2 µg Source Wheat Germ Species Human

Caspase-3 Recombinant Protein - H00000836-P01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Caspase-3 Partial Recombinant Protein - H00000836-Q02 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

Caspase-3 Partial Recombinant Protein - H00000836-Q01 from Novus Biologicals Category Protein Prices $369.00 Sizes 10 µg Species Human

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