| Gene Symbol |
Tcf3
|
| Entrez Gene |
21423
|
| Alt Symbol |
A1, AA408400, ALF2, AW209082, E12, E12/E47, E2A, E47, ME2, Pan1, Pan2, TCF-3, Tcfe2a, VDIR, bHLHb21
|
| Species |
Mouse
|
| Gene Type |
protein-coding
|
| Description |
transcription factor 3
|
| Other Description |
immunoglobulin enhancer-binding factor E12/E47|transcription factor A1|transcription factor E2-alpha|transcription factor E2a
|
| Swissprots |
Q3U153 Q9CYJ4 P15806 Q922S2 Q8VCY4 Q8CAH9 Q99MB8
|
| Accessions |
BAC65347 EDL31541 EDL31542 EDL31543 EDL31544 EDL31545 P15806 AF352579 AAK18618 AK014300 BAB29255 AK017617 BAB30842 AK034777 AK038738 BAC30118 AK146786 AK147735 AK156265 BAE33647 AK161009 AK170674 AK177640 AK185561 AK187839 AK192255 AK202741 AK205365 BC006860 AAH06860 BC018260 AAH18260 D16631 BAA04057 D16632 BAA04058 D16633 BAA04059 D16634 BAA04060 D16635 BAA04061 D16636 BAA04062 D16637 BAA04063 D16638 BAA04064 D29919 BAA06218 X17500 CAA35541 NM_001164147 NP_001157619 NM_001164148 NP_001157620 NM_001164149 NP_001157621 NM_001164150 NP_001157622 NM_001164151 NP_001157623 NM_001164152 NP_001157624 NM_001164153 NP_001157625 NM_011548 NP_035678
|
| Function |
Transcriptional regulator. Involved in the initiation of neuronal differentiation. Heterodimers between TCF3 and tissue- specific basic helix-loop-helix (bHLH) proteins play major roles in determining tissue-specific cell fate during embryogenesis, like muscle or early B-cell differentiation. Dimers bind DNA on E- box motifs: 5'-CANNTG-3'. Binds to the kappa-E2 site in the kappa immunoglobulin gene enhancer. Binds to IEB1 and IEB2, which are short DNA sequences in the insulin gene transcription control region. {ECO:0000269|PubMed:18214987}.
|
| Subcellular Location |
Nucleus.
|
| Top Pathways |
HTLV-I infection, Signaling pathways regulating pluripotency of stem cells, Transcriptional misregulation in cancer
|
