COX1

Gene Symbol COX1
Entrez Gene 4512
Alt Symbol COI, MTCO1
Species Human
Gene Type protein-coding
Description cytochrome c oxidase subunit I
Other Description -
Swissprots Q34770 P00395
Accessions AAB58945 YP_003024028
Function Cytochrome c oxidase is the component of the respiratory chain that catalyzes the reduction of oxygen to water. Subunits 1- 3 form the functional core of the enzyme complex. CO I is the catalytic subunit of the enzyme. Electrons originating in cytochrome c are transferred via the copper A center of subunit 2 and heme A of subunit 1 to the bimetallic center formed by heme A3 and copper B.
Subcellular Location Mitochondrion inner membrane; Multi-pass membrane protein.
Top Pathways Alzheimer's disease, Huntington's disease, Cardiac muscle contraction, Non-alcoholic fatty liver disease (NAFLD), Oxidative phosphorylation

Complex IV Human Enzyme Activity Dipstick Assay Kit - ab109876 from Abcam

Prices $354.00, $627.00
Sizes 30 tests, 90 tests
Abcam's enzyme activity assays apply a novel approach, whereby target enzymes are first immunocaptured from tissue or cell samples before subsequent functional analysis. Dipstick ELISA Kits extend this concept by utilizing the well-established lateral flow concept, wherein capture antibodies are striped onto nitrocellulose membrane and a wicking pad draws the sample through the antibody bands. All of our ELISA kits utilize highly validated monoclonal antibodies and proprietary buffers, which are able to capture even very large enzyme complexes in their fully-intact, functionally-active states.

Complex IV Human Protein Quantity Dipstick Assay Kit - ab109877 from Abcam

Prices $343.00
Sizes 48 tests
An example using ab109877 to quantify Complex IV levels using various concentration of human fibroblast extract. Shown is a 1:2 dilution series using a positive control sample. Approximately 7 to 8 dipsticks are suitable for covering the entire working range and the blank for background levels. In this example the dilution series starts with 10 µg of fibroblast extract. A one-site hyperbola line was generated for best-fit analysis using GraphPad.

Cytochrome-C Oxidase (Complex IV) Human Profiling ELISA Kit - ab124538 from Abcam

Category ELISA Kit
Sensitivity 20 µg/ml
Range 5 µg/ml - 1000 µg/ml
Example control sample curve of serially titrated HepG2 extract in the working range of the assay.

Cytochrome-c Oxidase (Complex IV) Human SimpleStep ELISA™ Kit - ab179880 from Abcam

Category ELISA Kit
Prices $484.00
Sizes 1 x 96 tests
Sensitivity 64 µg/ml
Range 70 µg/ml - 800 µg/ml
The HeLa lysate range was prepared as described in Section 9 of the protocol using a dilution factor of 1.4. Raw data values are shown in the table. Background-subtracted data values (mean +/- SD) are graphed.

Complex IV Human Enzyme Activity Microplate Assay Kit - ab109909 from Abcam

Category Cellular Assay
Prices $448.00
Sizes 96 tests
Abcam's enzyme activity assays apply a novel approach, whereby target enzymes are first immunocaptured from tissue or cell samples before subsequent functional analysis. All of our ELISA kits utilize highly validated monoclonal antibodies and proprietary buffers, which are able to capture even very large enzyme complexes in their fully-intact, functionally-active states.Capture antibodies are pre-coated in the wells of premium Nunc MaxiSorp™ modular microplates, which can be broken into 8-well strips. After the target has been immobilized in the well, substrate is added, and enzyme activity is analyzed by measuring the change in absorbance of either the substrate or the product of the reaction (depending upon which enzyme is being analyzed). By analyzing the enzyme's activity in an isolated context, outside of the cell and free from any other variables, an accurate measurement of the enzyme's functional state can be understood.

Complex IV Human Specific Activity Microplate Assay Kit - ab109910 from Abcam

Category Cellular Assay
Prices $510.00
Sizes 96 tests
Functional study using Complex IV Human Specific Activity Microplate Assay Kit (ab109910).

Complex IV Immunocapture Kit - ab109801 from Abcam

Category Cellular Assay
Prices $386.00
Sizes 250 µg
Complex IV immunoprecipitation using antibody ab109863/MS101c crosslinked to protein G-agarose beads as product ab109801

MitoTox™ Complex IV OXPHOS Activity Microplate Assay - ab109906 from Abcam

Category Cellular Assay
Prices $448.00
Sizes 96 tests

Human MT-CO1 / COX1 ELISA Kit (Sandwich ELISA) - LS-F11180 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity 78
Range 78-5000 pg/ml

Cytochrome c oxidase subunit 1 (MT-CO1), Human, ELISA Kit - CSB-EL015072HU from ARP American Research Products

Category ELISA Kit
Prices $495.00, $695.00, $696.00, $699.00
Sizes 48 t, 96 t, 5 x 96t, 10 x 96t

mitochondrially encoded cytochrome c oxidase I, ELISA Kit - MBS930339 from MyBioSource

Category ELISA Kit
Prices $250.00, $495.00, $710.00, $2,705.00, $5,145.00
Sizes 24 -strip-wells (Limit 1), 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Sensitivity Typically less than 6.25 pg/ml
Range 25 pg/ml-1600 pg/ml.

ELISA Kit for Cytochrome C Oxidase Subunit I (COX1) - SED283Hu from Uscn Life Science Inc.

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA’s were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Human Cytochrome c oxidase subunit 1(MT-CO1) ELISA kit - CSB-EL015072HU from Cusabio

Category ELISA Kit
Sensitivity 6.25pg/ml
Range 25 pg/ml-1600 pg/ml

ELISA Kit for Cytochrome C Oxidase Subunit I (COX1) - SED283Hu from Cloud-clone

Category ELISA Kit
Sensitivity The minimum detectable dose of this kit is typically less than 0.122ng/mL.
Range 0.313-20ng/mL The standard curve concentrations used for the ELISA's were 20ng/mL, 10ng/mL, 5ng/mL, 2.5ng/mL, 1.25ng/mL, 0.625ng/mL, 0.313ng/mL

Dog MT-CO1 / COX1 ELISA Kit (Custom ELISA) - LS-F20170 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 78-5000 pg/ml

Bovine MT-CO1 / COX1 ELISA Kit (Custom ELISA) - LS-F20172 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 78-5000 pg/ml

Rat MT-CO1 / COX1 ELISA Kit (Custom ELISA) - LS-F20173 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 78-5000 pg/ml

Chicken MT-CO1 / COX1 ELISA Kit (Custom ELISA) - LS-F20168 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 78-5000 pg/ml

Pig MT-CO1 / COX1 ELISA Kit (Custom ELISA) - LS-F20167 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range 78-5000 pg/ml

Mouse MT-CO1 / COX1 ELISA Kit (Custom ELISA) - LS-F20169 from LifeSpan Bioscience

Category ELISA Kit
Prices $600.00
Sizes 1 plate
Sensitivity To be determined
Range 78-5000 pg/ml

Rabbit MT-CO1 / COX1 ELISA Kit - LS-F20171 from LifeSpan Bioscience

Category ELISA Kit
Prices $700.00
Sizes 1 plate
Sensitivity To be determined
Range To be determined

Human MT-CO1 / COX1 ELISA Kit (Sandwich ELISA) - LS-F25415 from LifeSpan Bioscience

Category ELISA Kit
Prices $780.00
Sizes 1 plate
Sensitivity 0.122 ng/ml
Range 78-5000 pg/ml

Human Cytochrome c oxidase subunit 1 ELISA Kit - EK5118 from Signalway Antibody

Category ELISA Kit
Prices $559.00
Sizes 1x96t
Range 78.0 pg ml - 5000 pg ml

Cytochrome c oxidase subunit 1, ELISA Kit - MBS2887305 from MyBioSource

Category ELISA Kit
Prices $430.00, $570.00, $2,515.00, $4,520.00
Sizes 48 -strip-wells, 96 -strip-wells, 5x96-strip-wells, 10x96-strip-wells
Range 78.0 pg/ml -5000 pg/ml

Cytochrome c oxidase subunit 1, ELISA Kit - MBS9428944 from MyBioSource

Category ELISA Kit
Prices $520.00
Sizes 96 tests
Range 78.0 pg/mL-5000 pg/mL
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