ULK2

Gene Symbol	ULK2
Entrez Gene	9706
Alt Symbol	ATG1B, Unc51.2
Species	Human
Gene Type	protein-coding
Description	unc-51 like autophagy activating kinase 2
Other Description	serine/threonine-protein kinase ULK2
Swissprots	O75119 A8MY69 Q8IYT8
Accessions	EAW50910 EAW50911 EAW50912 Q8IYT8 AB014523 BAA31598 AK098316 BAG53611 AK314345 AL080134 BC034988 AAH34988 BC039310 DA105030 XM_011524087 XP_011522389 XR_934124 XR_934125 NM_001142610 NP_001136082 NM_014683 NP_055498
Function	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic
Subcellular Location	Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18936157}; Peripheral membrane protein {ECO:0000269|PubMed:18936157}. Note=Localizes to pre- autophagosomal membrane.
Top Pathways	Regulation of autophagy, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

ULK2 overexpression lysate - LY428207 from Acris Antibodies Category Cell Lysate Prices $480.00 Sizes 100 µg

ULK2 293 Cell Lysate - 402078 from ABBIOTEC Category Cell Lysate Prices $392.00 Sizes 100 µg Species C. elegans

ULK2 Overexpression Lysate (Native) - NBL1-17608 from Novus Biologicals Category Cell Lysate Prices $329.00 Sizes 100 µg

ULK2 Over-expression Lysate Product - GWB-3D276D from Genway Biotech Category Cell Lysate Prices $445.00 Sizes 100 µg Species Human

ULK2 Overexpression Lysate (Native) - NBP2-09663 from Novus Biologicals Category Cell Lysate Prices $529.00 Sizes 100 µg

Panoply™ Human ULK2 Knockdown Stable Cell Line - CSC-DC017077 from Creative biogene Category Cell Line Species Human

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