ULK2

Gene Symbol	ULK2
Entrez Gene	9706
Alt Symbol	ATG1B, Unc51.2
Species	Human
Gene Type	protein-coding
Description	unc-51 like autophagy activating kinase 2
Other Description	serine/threonine-protein kinase ULK2
Swissprots	O75119 A8MY69 Q8IYT8
Accessions	EAW50910 EAW50911 EAW50912 Q8IYT8 AB014523 BAA31598 AK098316 BAG53611 AK314345 AL080134 BC034988 AAH34988 BC039310 DA105030 XM_011524087 XP_011522389 XR_934124 XR_934125 NM_001142610 NP_001136082 NM_014683 NP_055498
Function	Serine/threonine-protein kinase involved in autophagy in response to starvation. Acts upstream of phosphatidylinositol 3- kinase PIK3C3 to regulate the formation of autophagophores, the precursors of autophagosomes. Part of regulatory feedback loops in autophagy: acts both as a downstream effector and a negative regulator of mammalian target of rapamycin complex 1 (mTORC1) via interaction with RPTOR. Activated via phosphorylation by AMPK, also acts as a negative regulator of AMPK through phosphorylation of the AMPK subunits PRKAA1, PRKAB2 and PRKAG1. May phosphorylate ATG13/KIAA0652, FRS2, FRS3 and RPTOR; however such data need additional evidences. Not involved in ammonia-induced autophagy or in autophagic response of cerebellar granule neurons (CGN) to low potassium concentration. Plays a role early in neuronal differentiation and is required for granule cell axon formation: may govern axon formation via Ras-like GTPase signaling and through regulation of the Rab5-mediated endocytic
Subcellular Location	Cytoplasmic vesicle membrane {ECO:0000269|PubMed:18936157}; Peripheral membrane protein {ECO:0000269|PubMed:18936157}. Note=Localizes to pre- autophagosomal membrane.
Top Pathways	Regulation of autophagy, mTOR signaling pathway

• Antibodies
• Assays/Kits
• Proteins/Peptides
• siRNAs/Functional Genomics
• cDNA Clones
• Cell/Tissue/Blood Products

Active human ULK2 protein fragment - ab125622 from Abcam Category Protein Prices $302.00 Sizes 5 µg Source Baculovirus infected sf9 cells Species Human

Human ULK2 protein fragment - ab153013 from Abcam Category Protein Source Wheat germ Species Human

ULK2 Antibody Blocking Peptide - LS-E7554 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

ULK2 Antibody Blocking Peptide - LS-E31436 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 50 µg

ULK2 Antibody Blocking Peptide - LS-E9499 from LifeSpan Bioscience Category Peptide Prices $145.00 Sizes 100 µg

Recombinant Human ULK2 Protein - H00009706-Q01 from Novus Biologicals Category Protein Prices $369.00, $529.00 Sizes 10 µg, 25 µg Source Wheat Germ Species Human

ULK2-Antibody-Center-S323-Blocking-Peptide - BP19251c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

Phospho-ULK2S323-Antibody-Blocking-peptide - BP3806a from Abgent, a WuXi AppTec company Category Peptide Prices $120.00 Sizes 100 µg

ULK2-Antibody-C-term-Blocking-Peptide - BP8105b from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ULK2 peptide - orb218899 from Biorbyt Category Peptide Prices $272.00, $510.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

ULK2 Blocking Peptide - abx064230 from Abbexa Category Peptide Species Human, Mouse, Rat

Unc-51-like kinase 2 (ULK2) - H00009706-Q01-10 from Acris Antibodies Category Protein Prices $380.00 Sizes 10 µg Source in vitro transl. Species Human

Unc-51-like kinase 2 (ULK2) - H00009706-Q01-25 from Acris Antibodies Category Protein Prices $500.00 Sizes 25 µg Source in vitro transl. Species Human

ULK2 Peptide - 7337P from ProSci Category Peptide Species Human

ULK2 fusion protein - ag14604 from Proteintech Group Category Protein Source E. coli-derived, PET28a Species Human

ULK2 fusion protein - Ag3695 from Proteintech Group Category Protein Prices $199.00 Sizes 50 μg Source E. coli -derived, PGEX-4T Species Human

Recombinant Human Unc-51-Like Kinase 2 (C. elegans), GST-tagged, Active - ULK2-456H from Creative Biomart Category Protein Source Sf9 insect cells using baculovirus.

Recombinant Human Unc-51-Like Kinase 2 (C. elegans), GST-tagged - ULK2-1115H from Creative Biomart Category Protein Species Human

ULK2, active - 14-772M from EMD Millipore Prices $2,544.00 Sizes 250 µg also available in 10μg size as catalog # 14-772 and in 250 μg as catalog # 14-772m. Source N-terminal GST and C-terminal 6His-tagged, recombinant, human, ULK2, amino acids 1–306. Expressed by baculovirus in Sf21 insect cells

ULK2, active - 14-772 from EMD Millipore Prices $401.00 Sizes 10 µg also available in 250μg size as catalog # 14-772m and in bulk as catalog # 14-772-k. Source N-terminal GST and C-terminal 6His-tagged, recombinant, human, ULK2, amino acids 1–306. Expressed by baculovirus in Sf21 insect cells

ULK2 Blocking Peptide - CBP3036 from Cohesion Biosciences Category Peptide Prices $100.00, $300.00 Sizes 1 mg, 5 mg Species Human, Mouse, Rat

Recombinant Human Serine/threonine-protein kinase ULK2(ULK2) ,partial - CSB-YP811629HU CSB-EP811629HU CSB-BP811629HU CSB-MP811629HU from Cusabio Category Protein Source Yeast or E.coli or Baculovirus or Mammalian cell Species Human

ULK2 Recombinant Protein Antigen - NBP1-88881PEP from Novus Biologicals Category Protein Prices $199.00 Sizes 100 µl Source E.coli Species Human

ULK2-Blocking-Peptide-Center - BP8105c from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

ULK2-Blocking-Peptide-N-term - BP8105a from Abgent, a WuXi AppTec company Category Peptide Prices $80.00 Sizes 100 µg

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