SCNN1B

Gene Symbol SCNN1B
Entrez Gene 6338
Alt Symbol BESC1, ENaCb, ENaCbeta, SCNEB
Species Human
Gene Type protein-coding
Description sodium channel, non voltage gated 1 beta subunit
Other Description amiloride-sensitive sodium channel subunit beta|amiloride-sensitive sodium channel subunit beta 1|beta-ENaC|beta-NaCH|epithelial Na(+) channel subunit beta|epithelial sodium channel beta-2 subunit|epithelial sodium channel beta-3 subunit|nasal epithelial sodium channel beta subunit|nonvoltage-gated sodium channel 1 subunit beta|sodium channel, non-voltage-gated 1, beta subunit|sodium channel, nonvoltage-gated 1, beta
Swissprots Q96KG2 Q9UMU5 O60891 C5HTZ2 Q9UJ32 P51168
Accessions AAA67036 AAL48196 AAL48197 ACS13723 ACS13724 CAA06508 EAW55833 EAW55834 P51168 AF260226 AAK49394 AK313192 BAG36009 AU105979 BC036352 AAH36352 DQ402523 ABD72219 EU831785 ACE87303 EU831863 ACE86622 HQ257906 ADR82661 L36593 AAA75459 X87159 CAA60632 XM_011545913 XP_011544215 XM_011545914 XP_011544216 NM_000336 NP_000327
Function Sodium permeable non-voltage-sensitive ion channel inhibited by the diuretic amiloride. Mediates the electrodiffusion of the luminal sodium (and water, which follows osmotically) through the apical membrane of epithelial cells. Plays an essential role in electrolyte and blood pressure homeostasis, but also in airway surface liquid homeostasis, which is important for proper clearance of mucus. Controls the reabsorption of sodium in kidney, colon, lung and sweat glands. Also plays a role in taste perception. {ECO:0000269|PubMed:24124190}.
Subcellular Location Apical cell membrane {ECO:0000269|PubMed:24124190}; Multi-pass membrane protein {ECO:0000269|PubMed:24124190}. Note=Apical membrane of epithelial cells.
Tissue Specificity Expressed in kidney (at protein level). {ECO:0000269|PubMed:22207244}.
Top Pathways Taste transduction, Aldosterone-regulated sodium reabsorption

βENaC (D-3) - sc-25354 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
βENaC (D-3): sc-25354. Western blot analysis of βENaC expression in KNRK whole cell lysate.

βENaC (H-190) - sc-21013 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Rabbit
Clonality Polyclonal
βENaC (H-190): sc-21013. Western blot analysis of βENaC expression in non-transfected: sc-117752 (A) and human βENaC transfected: sc-177183 (B) 293T whole cell lysates.

βENaC (C-20) - sc-22242 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Goat
Clonality Polyclonal
βENaC (C-20): sc-22242. Western blot analysis of βENaC expression in non-transfected: sc-117752 (A) and human βENaC transfected: sc-177183 (B) 293T whole cell lysates.

βENaC (E-10) - sc-48428 from Santa Cruz Biotechnology

Prices $279.00
Sizes 200 µg/ml
Host Mouse
Clonality Monoclonal
bENaC (E-10): sc-48428. Western blot analysis of bENaC expression in KNRK whole cell lysate.

Anti-SCNN1B (phospho T615) antibody - ab79172 from Abcam

Prices $370.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
All lanes : Anti-SCNN1B (phospho T615) antibody (ab79172) at 1/500 dilutionLane 1 : extracts from HeLa cellsLane 2 : extracts from HeLa cells with immunizing phosphopeptide at 10 µgLysates/proteins at 10 µg per lane.

Anti-SCNN1B antibody - ab2906 from Abcam

Prices $378.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC image of SCNN1B staining in Human skeletal muscle formalin fixed paraffin embedded tissue section, performed on a Leica BondTM system using the standard protocol F. The section was pre-treated using heat mediated antigen retrieval with sodium citrate buffer (pH6, epitope retrieval solution 1) for 20 mins. The section was then incubated with ab2906, 5µg/ml, for 15 mins at room temperature and detected using an HRP conjugated compact polymer system. DAB was used as the chromogen. The section was then counterstained with haematoxylin and mounted with DPX.For other IHC staining systems (automated and non-automated) customers should optimize variable parameters such as antigen retrieval conditions, primary antibody concentration and antibody incubation times.

Anti-SCNN1B antibody - ab65711 from Abcam

Host Rabbit
Clonality Polyclonal

Anti-SCNN1B antibody - ab21795 from Abcam

Prices $359.00
Sizes 100 µl
Host Mouse
Clonality Polyclonal
All lanes : Anti-SCNN1B antibody (ab21795) at 1/1000 dilutionLane 1 : Total protein extract from E. coli with ~50ng to 100ng of a negative control fusion protein with an irrelevant antigen at 20 ug Lane 2 : Total protein extract from E. coli with ~50ng to 500ng of the antigen fusion protein at 20 ug SecondaryRabbit anti-mouse IgG + IgM, (H+L) horseradish peroxidase conjugated at 1/5000 dilution

Anti-SCNN1B antibody - ab172276 from Abcam

Prices $376.00
Sizes 50 µg
Host Mouse
Clonality Polyclonal
All lanes : Anti-SCNN1B antibody (ab172276) at 1 µg/mlLane 1 : SCNN1B transfected 293T cell line lysateLane 2 : 293T cell line lysate (non-transfected)Lysates/proteins at 15 µl per lane.SecondaryGoat anti-mouse HRP conjugated antibody at 1/2500 dilutiondeveloped using the ECL technique

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 488) - LS-C230326 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 565) - LS-C230327 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 594) - LS-C230328 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 633) - LS-C230329 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 655) - LS-C230330 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 680) - LS-C230331 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Atto 700) - LS-C230332 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, AP) - LS-C230333 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, APC) - LS-C230334 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, Biotin) - LS-C230335 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, FITC) - LS-C230336 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa581-630) - LS-C199336 from LifeSpan Bioscience

Prices $315.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal
IHC of paraffin-embedded human brain tissue, using Nonvoltage-gated Sodium Channel 1 Antibody. The sample on the right was incubated with synthetic peptide.

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, PE, Atto 594) - LS-C230338 from LifeSpan Bioscience

Prices $415.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, PerCP) - LS-C230339 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa617-638, RPE) - LS-C230340 from LifeSpan Bioscience

Prices $405.00
Sizes 100 µg
Host Rabbit
Clonality Polyclonal

Anti-SCNN1B / ENaC Beta Antibody (aa523-572) - LS-C206107 from LifeSpan Bioscience

Prices $365.00
Sizes 50 µg
Host Rabbit
Clonality Polyclonal
SCNN1B / ENaC Beta antibody Western Blot of 721_B. Antibody dilution: 1 ug/ml.
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